Pregna-1,4-diene-3,20-dione, 11β,17-dihydroxy-, 17-propionate (8CI)

Name	11beta,17-dihydroxypregna-1,4-diene-3,20-dione 17-propionate
Synonyms	RD 20000 Deprodone propionate (JAN) 21-Deoxyprednisolone 17-propionate 21-Deoxyprednisolone 17α-propionate 11beta,17-dihydroxypregna-1,4-diene-3,20-dione 17-propionate Pregna-1,4-diene-3,20-dione, 11-hydroxy-17-(1-oxopropoxy)-, (11β)- Pregna-1,4-diene-3,20-dione, 11β,17-dihydroxy-, 17-propionate (8CI)
CAS	20424-00-4
EINECS	243-810-1

Molecular Formula	C24H32O5
Molar Mass	400.51
Density	1.20±0.1 g/cm3(Predicted)
Melting Point	227-229 °C
Boling Point	540.6±50.0 °C(Predicted)
pKa	14.09±0.70(Predicted)
Storage Condition	Room Temprature
Physical and Chemical Properties	White to yellow powder, odorless, slightly bitter taste. Easily soluble in chloroform, hardly soluble in ether, insoluble in water. Melting point 228-229 ℃.
In vitro study	Deprodone propionate as an effective ingredient, can exhibit its effects to the maximum extent and over a prolonged period of time, do not have skin irritation, and are physicochemically stable. Deprodone propionate can be maintained in a stably suspended state owing to the thickening action of the suspending agent.

biological activity	Deprodone propylene (RD20000) is a corticosteroid, obtained by esterification of predisolone at position 17 with propionic acid and dehydrogenation at position 21.
Use	topical anti-inflammatory corticosteroids. For anti-inflammatory and anti-allergic.
production method	Method 1:21-deoxy-dehydrocortisol is oxidized to 21-deoxy-dehydrocortisone in acetic acid with chromium trioxide-manganese nitrate and then esterified with propionic anhydride under the catalysis of p-toluenesulfonic acid, again, potassium borohydride was reduced to desperione propionate. Method 2:21-o-methanesulfonyl dehydrocortisol acts in acetic acid with Acetyl nitrate to produce 21-o-methanesulfonyl -11-o-Nitro dehydrocortisol. Then in acetic acid, and sodium iodide and sodium bisulfite to produce 21-deoxy -11-o-nitro-dehydrocortisol. Further esterification with propionic anhydride and denitro removal with zinc dust-acetic acid gave dipirone propionate.

Last Update：2024-04-09 21:01:54

Spot supply

Product Name: RD20000 Visit Supplier Webpage Request for quotation
CAS: 20424-00-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
　　　　 tech@medchemexpress.com
Mobile: 609-228-6898

Spot supply

Product Name: Deprodone propionate (RD20000) Visit Supplier Webpage Request for quotation
CAS: 20424-00-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328

WhatsApp: +86-18821248368

Product Name: 11beta,17-dihydroxypregna-1,4-diene-3,20-dione 17-propionate Visit Supplier Webpage Request for quotation
CAS: 20424-00-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Spot supply

Product Name: RD20000 Visit Supplier Webpage Request for quotation
CAS: 20424-00-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
　　　　 tech@medchemexpress.com
Mobile: 609-228-6898

Spot supply

Product Name: Deprodone propionate (RD20000) Visit Supplier Webpage Request for quotation
CAS: 20424-00-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328

WhatsApp: +86-18821248368

View History

Pregna-1,4-diene-3,20-dione, 11β,17-dihydroxy-, 17-propionate (8CI) Request for Quotation