Molecular Formula | C26H24N6O4S |
Molar Mass | 516.57 |
Melting Point | 284-286℃ |
Boling Point | 506.9℃ at 760 mmHg |
Solubility | DMSO <1 mg/mL Water 22 mg/mL Ethanol <1 mg/mL |
Appearance | Crystalline powder |
Color | Orange to Amber to Dark red |
BRN | 3921806 |
PH | pH (1g/l, 25℃) : 4.0~8.0 |
Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
MDL | MFCD00013150 |
Use | This product is for scientific research only and shall not be used for other purposes. |
In vitro study | Proflavine acts as a Rev inhibitor by targeting the high-affinity Rev binding site, the HIV-1 Rev response element. |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
WGK Germany | 3 |
RTECS | AR9065100 |
FLUKA BRAND F CODES | 3-8-10-23 |
EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
biological activity | Proflavine hematinate is a preservative for external use that disrupts DNA synthesis by chelating DNA, and lead to high levels of mutations in the replicated DNA strands. |
Animal Model: | Adult male Sprague Dawley rats (weighing approximately 200 g) |
Dosage: | 20 mg/kg (Pharmacokinetic Analysis) |
Administration: | Intravenous injection; 2, 4, 5, 10, 15, 20, 25, and 30 min after dosing |
Result: | Concentration decreased rapidly from whole blood in the first 5 min after dosing, followed by a slower decrease. |