Proline, 1-(phenylmethyl)-
N-(benzyl)-l-proline
CAS: 31795-93-4
Molecular Formula: C12H15NO2
Proline, 1-(phenylmethyl)- - Names and Identifiers
| Name | N-(benzyl)-l-proline |
| Synonyms | Bzl-Pro-OH 1-Benzylproline (S)-Benzylproline N-Benzyl-L-Proline 1-benzyl-L-proline N-BENZYL-L-PROLINE 1-(benzyl)-L-proline N-(benzyl)-l-proline 1-(Phenylethyl)-l-proline (S)-1-N-(benzyl)-L-proline 1-(PhenylMethyl)-L-proline Proline, 1-(phenylmethyl)- (S)-1-N-(benzyl)-l-proline 1-(phenylnethyl)-L-proline L-Proline, 1-(phenylmethyl)- 1-benzylpyrrolidine-2-carboxylic acid (2S)-1-Benzylpyrrolidin-2-ylcarboxylic Acid |
| CAS | 31795-93-4 |
| InChI | InChI=1/C12H15NO2/c14-12(15)11-7-4-8-13(11)9-10-5-2-1-3-6-10/h1-3,5-6,11H,4,7-9H2,(H,14,15)/t11-/m0/s1 |
Proline, 1-(phenylmethyl)- - Physico-chemical Properties
| Molecular Formula | C12H15NO2 |
| Molar Mass | 205.25 |
| Density | 1.205 |
| Melting Point | 168-171°C |
| Boling Point | 343.1±35.0 °C(Predicted) |
| Flash Point | 161.3°C |
| Solubility | Acetone (Slightly), Dichloromethane (Slightly), Methanol (Slightly) |
| Vapor Presure | 2.76E-05mmHg at 25°C |
| Appearance | White solid |
| Color | White |
| pKa | 2.35±0.20(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.587 |
Proline, 1-(phenylmethyl)- - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Hazard Note | Irritant |
Proline, 1-(phenylmethyl)- - Introduction
N-(benzyl)-l-proline(N-(benzyl)-L-proline) is an organic compound with the following properties:
-molecular formula: C13H15NO2
-Molecular weight: 217.26g/mol
-Appearance: white crystalline powder or crystal
-Melting point: 70-73 degrees Celsius
-Solubility: Soluble in ethanol and chloroform, slightly soluble in water
N-(benzyl)-l-proline has certain applications in the field of medicinal chemistry:
-biological activity: N-(benzyl)-l-proline is a kind of unnatural amino acid, with inhibition of gallstone formation, anti-tumor, anti-inflammatory and other biological activity, can be used for drug research and development.
-carrier: N-(benzyl)-l-proline can be used as a protective group of peptide drugs and a catalyst for conversion reactions, and can be used for peptide chain extension, peptide chain modification and assembly in drug synthesis.
The method for preparing N-(benzyl)-l-proline mainly includes the following steps:
1. Synthesizing 1-benzyl -2-acetone (benzylacetone) from benzylacetone and photoammonia;
2.1-benzyl -2-acetone and N-benzyl-L-proline through oxidation reaction, through dehydration, alkylation and other steps to synthesize N-(benzyl)-l-proline.
Regarding safety information, the toxicity of N-(benzyl)-l-proline is relatively low, but the following matters still need to be noted:
-Eye and skin contact: Avoid prolonged contact with eyes and skin, and rinse immediately.
-Inhalation: Avoid inhaling dust and maintain good ventilation.
-Ingestion: Pay attention to personal hygiene, avoid accidental ingestion, and seek medical attention immediately if accidentally ingested.
During the use of N-(benzyl)-l-proline, the relevant laboratory safety practices should be observed, and appropriate personal protective measures such as laboratory gloves, glasses and protective clothing should be used.
-molecular formula: C13H15NO2
-Molecular weight: 217.26g/mol
-Appearance: white crystalline powder or crystal
-Melting point: 70-73 degrees Celsius
-Solubility: Soluble in ethanol and chloroform, slightly soluble in water
N-(benzyl)-l-proline has certain applications in the field of medicinal chemistry:
-biological activity: N-(benzyl)-l-proline is a kind of unnatural amino acid, with inhibition of gallstone formation, anti-tumor, anti-inflammatory and other biological activity, can be used for drug research and development.
-carrier: N-(benzyl)-l-proline can be used as a protective group of peptide drugs and a catalyst for conversion reactions, and can be used for peptide chain extension, peptide chain modification and assembly in drug synthesis.
The method for preparing N-(benzyl)-l-proline mainly includes the following steps:
1. Synthesizing 1-benzyl -2-acetone (benzylacetone) from benzylacetone and photoammonia;
2.1-benzyl -2-acetone and N-benzyl-L-proline through oxidation reaction, through dehydration, alkylation and other steps to synthesize N-(benzyl)-l-proline.
Regarding safety information, the toxicity of N-(benzyl)-l-proline is relatively low, but the following matters still need to be noted:
-Eye and skin contact: Avoid prolonged contact with eyes and skin, and rinse immediately.
-Inhalation: Avoid inhaling dust and maintain good ventilation.
-Ingestion: Pay attention to personal hygiene, avoid accidental ingestion, and seek medical attention immediately if accidentally ingested.
During the use of N-(benzyl)-l-proline, the relevant laboratory safety practices should be observed, and appropriate personal protective measures such as laboratory gloves, glasses and protective clothing should be used.
Last Update：2024-04-09 20:02:46
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CAS: 31795-93-4
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