Propanoyl bromide
Propionyl bromide
CAS: 598-22-1
Molecular Formula: C3H5BrO
Propanoyl bromide - Names and Identifiers
| Name | Propionyl bromide |
| Synonyms | PROPIONYL BROMIDE Propionyl bromide Propanoyl bromide 1-Bromo-1-propanone Propionic acid bromide Propanoic acid bromide |
| CAS | 598-22-1 |
| EINECS | 209-924-0 |
| InChI | InChI=1/C3H5BrO/c1-2-3(4)5/h2H2,1H3 |
| InChIKey | RIBFXMJCUYXJDZ-UHFFFAOYSA-N |
Propanoyl bromide - Physico-chemical Properties
| Molecular Formula | C3H5BrO |
| Molar Mass | 136.98 |
| Density | 1.521 g/mL at 25 °C (lit.) |
| Boling Point | 103-104 °C (lit.) |
| Flash Point | 126°F |
| Vapor Presure | 32.5mmHg at 25°C |
| Appearance | Tablets |
| Color | Gray-bluish |
| BRN | 1736651 |
| Storage Condition | Flammables area |
| Refractive Index | n20/D 1.455(lit.) |
| Physical and Chemical Properties | Colorless liquid. Boiling point 103-103.6 ℃(102.4kPa), relative density 1.5210(16/4 ℃), refractive index 1.4578(16 ℃). Flash point 52 °c. Soluble in ether, water, alcohol decomposition. |
| Use | Used as pharmaceutical intermediates, Organic synthesis |
Propanoyl bromide - Risk and Safety
| Hazard Symbols | C - Corrosive |
| Risk Codes | R10 - Flammable R14 - Reacts violently with water R34 - Causes burns |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2920 8/PG 2 |
| WGK Germany | 3 |
| HS Code | 29159000 |
| Hazard Class | 3.2 |
| Packing Group | III |
Propanoyl bromide - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| overview | propionyl bromide, colorless liquid. Soluble in ether. Toxic and corrosive, flammable, slightly less dangerous than acetyl bromide. When heated or decomposed in water and ethanol, toxic and corrosive hydrogen bromide gas is released. Used as a pharmaceutical intermediate and also used in organic synthesis. |
| Preparation method | 1. Propionyl bromide is synthesized by propionyl chloride in a yield of about 73%; Figure 1 shows the reaction equation for the synthesis of propionyl bromide 1 2. Synthesis of propionyl bromide by trimethylsilyl propionate Figure 2 shows the reaction equation for the synthesis of propionyl bromide 2 3. Synthesis of propionyl bromide by propionyl -1-ketone Figure 3 shows the reaction equation for the synthesis of propionyl bromide 3 |
| apply | for organic synthesis. Chemical drugs, pesticide intermediates. |
| safe use | 1. danger health hazard: it has irritating effect on eyes, mucous membrane, respiratory tract and skin, and can cause burns. Hazard of explosion: This product is flammable, highly corrosive and irritating, and can cause burns to the human body. 2. first aid measures skin contact: immediately remove the contaminated clothes and rinse with a large amount of flowing water for at least 15 minutes. Medical treatment. eye contact: immediately lift the eyelids and rinse thoroughly with a large amount of flowing water or normal saline for at least 15 minutes. Medical treatment. Inhalation: Quickly leave the scene to fresh air. Keep the airway unobstructed. If breathing is difficult, give oxygen. If breathing stops, artificial respiration is performed immediately. Medical treatment. Eating: Gargle with water and drink milk or egg white. Medical treatment. 3. Fire measures Hazard characteristics: flammable, decomposed by heat to release hydrogen bromide and highly toxic carbonyl bromide. It is violently decomposed with water and ethanol to produce bromohydroic acid and acetic acid. It is highly corrosive to most metals in case of tide. Harmful combustion substances: carbon monoxide, carbon dioxide, hydrogen bromide. Fire extinguishing method: Firefighters must wear full-body acid and alkali-resistant fire fighting clothing. Move the container from the fire to the open as far as possible. If the container in the fire field has changed color or produced sound from the safety pressure relief device, it must be evacuated immediately. Fire extinguishing agent: dry powder, carbon dioxide, sand. It is forbidden to extinguish fires with water and foam. 4. emergency treatment for leakage emergency treatment: quickly evacuate the personnel from the leaking contaminated area to the safe area, and carry out isolation to strictly restrict access. Cut off the fire. It is recommended that emergency personnel wear self-contained positive pressure respirators and anti-acid and alkali overalls. Cut off the leak source as much as possible. Prevent inflow into restricted spaces such as sewers and drainage ditches. Small amount of leakage: adsorption or absorption with sand or other non-combustible materials. It can also be scrubbed with an emulsion made of a non-combustible dispersant, and the lotion is diluted and put into the wastewater system. Large leakage: build dikes or dig pits to accommodate them. Transfer by pump to tank truck or special collector, recycle or transport to waste disposal site for disposal. 5. operation disposal and storage precautions for operation: airtight operation with partial air exhaust. Operators must undergo special training and strictly abide by the operating procedures. It is recommended that operators wear self-priming filter gas masks (full masks), rubber acid and alkali resistant clothing and rubber acid and alkali resistant gloves. Stay away from fire and heat sources. Smoking is strictly prohibited in the workplace. Use explosion-proof ventilation systems and equipment. Prevent vapor from leaking into the workplace air. Avoid contact with oxidants, alkalis, and alcohols. Pay special attention to avoid contact with water. When handling, it should be lightly loaded and unloaded to prevent damage to the packaging and containers. Equipped with corresponding varieties and quantities of fire fighting equipment and leakage emergency treatment equipment. Empty containers may remain harmful substances. storage precautions: store in a cool, dry and well-ventilated warehouse. Stay away from fire and heat sources. Keep the container sealed. Should be stored separately from oxidants, alkalis, alcohols, etc., avoid mixed storage. Explosion-proof lighting and ventilation facilities are adopted. It is forbidden to use mechanical equipment and tools that are prone to spark. The storage area shall be equipped with leakage emergency treatment equipment and suitable storage materials. 6. contact control/personal protection engineering control: airtight operation, local exhaust. Provide safe shower and eye washing equipment. respiratory system protection: when the concentration in the air exceeds the standard, you must wear a self-priming filter gas mask (full mask). An air respirator should be worn during emergency rescue or evacuation. Eye protection: The respiratory system has been protected. Body protection: wear rubber acid and alkali resistant clothing. Hand protection: Wear rubber acid and alkali resistant gloves. Other protection: After work, shower and change clothes. Store clothes contaminated with poison separately and wash them for later use. Pay attention to personal cleanliness. |
| Main reference materials | [1] Shen Panwen, editor-in-chief Wang Jitao. Compound dictionary. Shanghai: Shanghai Lexicographic Publishing House. 2002. Page 318. [2]http://www.aladdin-e.com/zh_cn/p107847.html. [3]http://baike.molbase.cn/cidian/32395. [4]http://www.xiyashiji.com/goods-9299.html. [5]http://lib.hsesystem.com/msds.do/show_1971/ |
| Use | Used as a pharmaceutical intermediate, organic synthesis Used for the synthesis of various derivatives of acetylene; the pharmaceutical industry is used to manufacture the antifungal drug chloroproparylene iodine. Used as a pharmaceutical intermediate for organic synthesis |
| Production method | Anhydrous propionic acid is obtained by reacting with bromine in the presence of red phosphorus. |
Last Update：2024-04-10 22:29:15
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