Propargylic acid
Propiolic acid
CAS: 471-25-0
Molecular Formula: C3H2O2
Propargylic acid - Names and Identifiers
| Name | Propiolic acid |
| Synonyms | prop-2-ynoate Propynoic acid PROPIOLIC ACID Propiolic acid PROPYNOIC ACID Propiolic acidd 2-Propynoic acid 2-PROPYNIOC ACID 2-PROPYNOIC ACID PROPARGYLIC ACID Propargylic acid prop-2-ynoic acid ACETYLENECARBOXYLIC ACID Propiolic acid, (Propynoic acid) Acetylenecarboxylic acid~Propargylic acid~Propynoic acid |
| CAS | 471-25-0 |
| EINECS | 207-437-8 |
| InChI | InChI=1/C3H2O2/c1-2-3(4)5/h1H,(H,4,5)/p-1 |
Propargylic acid - Physico-chemical Properties
| Molecular Formula | C3H2O2 |
| Molar Mass | 70.05 |
| Density | 1.138 g/mL at 25 °C (lit.) |
| Melting Point | 16-18 °C (lit.) |
| Boling Point | 102 °C/200 mmHg (lit.) |
| Flash Point | 138°F |
| Water Solubility | miscible |
| Vapor Presure | 3.65mmHg at 25°C |
| Appearance | Liquid After Melting |
| Specific Gravity | 1.138 |
| Color | Clear colorless to light brown |
| Merck | 14,7821 |
| BRN | 878176 |
| pKa | 1.84(at 25℃) |
| Storage Condition | 2-8°C |
| Stability | Stable. Incompatible with bases, oxidizing agents, reducing agents. Combustible. |
| Refractive Index | n20/D 1.431(lit.) |
| Physical and Chemical Properties | Character: colorless liquid. melting point 18 ℃ boiling point 144 ℃ (decomposition) relative density 1.1380 refractive index 1.4302 flash point 58 ℃ solubility, ether and chloroform were miscible. |
| Use | Used as an intermediate in organic synthesis, can be catalyzed with methanol in sulfuric acid to generate methyl propiolate, is the raw material for the production of antiviral drug iodine |
Propargylic acid - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R24/25 - R34 - Causes burns R25 - Toxic if swallowed R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S24/25 - Avoid contact with skin and eyes. S7/9 - |
| UN IDs | UN 2920 8/PG 2 |
| WGK Germany | 3 |
| RTECS | UD9300000 |
| FLUKA BRAND F CODES | 3-8 |
| TSCA | Yes |
| HS Code | 29161980 |
| Hazard Class | 8 |
| Packing Group | II |
Propargylic acid - Nature
Open Data Verified Data
colorless liquid, melting point 8.85 °c. Boiling point 143.85 °c. The relative density was 1.1435. Refractive index 1.4302. It has the dual characteristics of alkynes and carboxylic acids, and can carry out reduction, addition, oxidation, esterification and cyclization, and the formation of salts and acid chlorides.
Last Update：2024-01-02 23:10:35
Propargylic acid - Preparation Method
Open Data Verified Data
with sodium acetylene and CO2 in 3.55~7. 09MPa and 90 deg C temperature below the reaction.
Last Update：2022-01-01 10:31:29
Propargylic acid - Use
Open Data Verified Data
It can be used for preparing propionic acid, pyromellitic acid, halogenated acrylic acid, dihalogenated acrylic acid, diacetylene dicarboxylic acid, ethyl propiolate, pyrazolone, Dibromo crotonic acid, ethoxy crotonic acid and the like.
Last Update：2022-01-01 10:31:29
Propargylic acid - Safety
Open Data Verified Data
is corrosive and highly irritating to the skin, eyes and mucous membranes. Skin contact can cause burns. Wear a gas mask and gloves. Eye irritation, skin contact with a large amount of water rinse. According to the general provisions of the storage and transportation of chemicals.
Last Update：2022-01-01 10:31:30
Propargylic acid - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Biological activity | Propiolic acid (Acetylene carboxylic acid, Propargylic acid, Acetylene mono-carboxylic acid) is an alkyne fatty acid, a single unsaturated fatty acid, used in chemical synthesis. Obtained a hazardous chemicals business license |
| Use | Used as an intermediate in organic synthesis, it can be used with methanol to generate methyl propionate under sulfuric acid catalysis. It is a raw material for the production of antiviral drug iodopside Used in organic synthesis. It can be used to prepare propionic acid, pyromellitic acid, halogenated acrylic acid, dihalogenated acrylic acid, diacetylene dicarboxylic acid, ethyl propionate, pyrazolone, dibromocrotonic acid, ethoxycrotonic acid, etc. Propionic acid, sulfuric acid, and methanol can be heated and refluxed to produce methyl propionate (C4H4O2,[922-67-8]), which is the raw material of the antiviral drug iodopside. Used in the synthesis of transition metal complexes, haloalkylpropionylates and haloacrylates |
| Production method | 1. It is obtained by oxidation of propargyl alcohol. Add propargyl alcohol to acetone and stir, add sulfuric acid solution of chromic anhydride dropwise at 20 ℃, finish the addition, and stir at room temperature for 14 hours to generate propargylic acid. 2. The reaction of sodium acetylene and CO2 at 3.55-7.09MPa and below 90 ℃ is obtained. |
| category | corroded articles |
| toxicity classification | highly toxic |
| acute toxicity | oral-rat LC50: 100 mg/kg; Oral-mouse LD50: 100 mg/kg |
| flammability hazard characteristics | combustible when heated |
| storage and transportation characteristics | warehouse ventilation and low temperature drying; Separate storage with oxidant and alkali |
| fire extinguishing agent | water, carbon dioxide, sand |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-10 22:29:15
Supplier List
Spot supply
Product Name: Propiolic acid Request for quotationCAS: 471-25-0
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Product Name: Propiolic acid Request for quotation
CAS: 471-25-0
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
CAS: 471-25-0
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Product Name: Propiolic acid Request for quotation
CAS: 471-25-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 471-25-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Spot supply
Product Name: Propiolic acid Request for quotationCAS: 471-25-0
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Product Name: Propiolic acid Request for quotation
CAS: 471-25-0
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
CAS: 471-25-0
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Product Name: Propiolic acid Request for quotation
CAS: 471-25-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 471-25-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
View History