Pseurotin A
Pseurotin A
CAS: 58523-30-1
Molecular Formula: C22H25NO8
Pseurotin A - Names and Identifiers
Pseurotin A - Physico-chemical Properties
| Molecular Formula | C22H25NO8 |
| Molar Mass | 431.44 |
| Density | 1.41±0.1 g/cm3(Predicted) |
| Melting Point | 126.0-126.9℃ |
| Boling Point | 751.5±60.0 °C(Predicted) |
| Solubility | Soluble in DMSO (10 mg/ml) |
| Appearance | White to off-white powder. |
| Color | White |
| pKa | 14.76±0.20(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
Pseurotin A - Reference Information
| biological activity | pseutin A, A secondary metabolite of Aspergillus and other fungi, is chitin synthase competitive inhibitors and neurogenesis agents. Pseudotin A inhibited the production of IgE (IC50=3.6 μm). Pseudotin A has anti-tumor activity. |
| Cell Line: | BT-474 cells, T47D cells |
| Concentration: | 40-200 μM |
| Incubation Time: | 24-72 hours |
| Result: | Showed weak but time and dose-dependent inhibition of the growth of BT-474 and T47D BC cells, with gradual decrease of the IC 50 values over time (260.83-93.64 μM and 267.84-113.08 μM, respectively). Significantly suppressed the growth of BT474 tumors. |
| Animal Model: | HFD-fed orthotopic athymic mice (bearing BT-474 tumor cells xenograft mode) |
| Dosage: | 10 mg/kg |
| Administration: | P.o.; 7X/week, 30 days |
Last Update：2024-04-09 21:49:45
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CAS: 58523-30-1
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CAS: 58523-30-1
Tel: 18301782025
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