Pyrazine, chloro- (6CI,7CI,8CI,9CI)
2-Chloropyrazine
CAS: 14508-49-7
Molecular Formula: C4H3ClN2
Pyrazine, chloro- (6CI,7CI,8CI,9CI) - Names and Identifiers
| Name | 2-Chloropyrazine |
| Synonyms | chloro-pyrazin CHLOROPYRAZINE 2-Chloropyrazine -Dichloropyrazine Pyrazine, chloro- 2-chloropiperazine CHLOROPYRAZINE, 2- Pyrazine, 2-chloro- 2-Chloro-1,4-diazine 2 - chloride pyrazine Pyrazin-2-yl chloride CHLOROPYRAZINE, 2-(SG) Pyrazine, chloro- (6CI,7CI,8CI,9CI) |
| CAS | 14508-49-7 |
| EINECS | 238-517-0 |
| InChI | InChI=1/C4H3ClN2/c5-4-3-6-1-2-7-4/h1-3H |
Pyrazine, chloro- (6CI,7CI,8CI,9CI) - Physico-chemical Properties
| Molecular Formula | C4H3ClN2 |
| Molar Mass | 114.53 |
| Density | 1.283 g/mL at 25 °C (lit.) |
| Melting Point | 153～154℃ |
| Boling Point | 153-154 °C (lit.) |
| Flash Point | 136°F |
| Water Solubility | INSOLUBLE |
| Solubility | Soluble in Methanol |
| Vapor Presure | 3.92mmHg at 25°C |
| Appearance | Liquid |
| Specific Gravity | 1.283 |
| Color | Clear colorless to yellow |
| BRN | 107019 |
| pKa | -1.10±0.10(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | n20/D 1.539(lit.) |
| Physical and Chemical Properties | Colorless or yellowish transparent liquid. |
| Use | Used as pharmaceutical, pesticide intermediates |
Pyrazine, chloro- (6CI,7CI,8CI,9CI) - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection |
| UN IDs | UN 1993 3/PG 3 |
| WGK Germany | 3 |
| TSCA | T |
| HS Code | 29339990 |
| Hazard Note | Irritant |
| Hazard Class | 3 |
| Packing Group | III |
Pyrazine, chloro- (6CI,7CI,8CI,9CI) - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | pharmaceutical intermediates used as pharmaceutical and pesticide intermediates |
| production method | feed ratio (mass) 2-hydroxypyrazine: phosphorus oxychloride = 1 :( 8~10) put 2-hydroxypyrazine and phosphorus oxychloride into the glass-lined chlorination kettle, turn on the stirring, steam heating and tail gas hydrogen chloride absorption system, slowly raise the temperature to reflux, and maintain stable reflux. After the reaction is finished, the phosphorus oxychloride is recovered by vacuum distillation, and the residual liquid is cooled to below 40 ℃, and slowly added dropwise into the water treatment kettle in which crushed ice is added in advance, followed by adding stone and ether for extraction for 2-3 times, and the extraction phase is combined, dried with anhydrous sodium sulfate, and then filtered, filtrate to vacuum distillation, first recovery extractant petroleum ether, and finally collected under 3.73kPa 59~62 deg C fraction, namely 2-chloropyrazine. Yield ≥ 80%. |
Last Update：2024-04-09 02:00:04
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