Pyrazinecarbonyl chloride

Pyrazinecarbonyl chloride - Names and Identifiers

Name	2-Pyrazinecarbonyl chloride
Synonyms	TIMTEC-BB SBB010290 ASINEX-REAG BAS 07703829 pyrazinecarbonyl chloride Pyrazinecarbonyl chloride 2-Pyrazinecarbonyl chloride 2-PYRAZINECARBONYL CHLORIDE Pyrazine-2-carbonyl chloride PYRAZINE-2-CARBONYL CHLORIDE PYRAZINE-2-CARBOXYLIC ACID CHLORIDE
CAS	19847-10-0
EINECS	243-367-4
InChI	InChI=1/C5H3ClN2O/c6-5(9)4-3-7-1-2-8-4/h1-3H

Pyrazinecarbonyl chloride - Physico-chemical Properties

Molecular Formula	C5H3ClN2O
Molar Mass	142.54
Density	1.393±0.06 g/cm3(Predicted)
Melting Point	41°C
Boling Point	214.5±20.0 °C(Predicted)
Flash Point	83.5°C
Water Solubility	Reacts with water.
Vapor Presure	0.155mmHg at 25°C
pKa	-2.50±0.10(Predicted)
Storage Condition	2-8°C
Sensitive	Moisture Sensitive
Refractive Index	1.551
MDL	MFCD00792886

Pyrazinecarbonyl chloride - Risk and Safety

Hazard Symbols	C - Corrosive
Risk Codes	34 - Causes burns
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	3265
Hazard Class	8
Packing Group	II

Pyrazinecarbonyl chloride - Introduction

2-Pyrazinecarbonyl chloride, also known as the formula ClCOCHC(NH2) = NC5H4, is an organic compound. The following is a description of the nature, use, formulation and safety information of 2-Pyrazinecarbonyl chloride:

Nature:
-Appearance: colorless liquid
-Molecular formula: C6H4ClNO
-Molecular weight: 141.56g/mol
-Boiling point: 260-261 ° C
-Density: 1.318g/cm³

Use:
2-Pyrazinecarbonyl chloride is mainly used in organic synthesis reactions and is commonly used as acylation reagent, substitution reagent and reaction intermediate. It has a wide range of applications in the construction of nitrogen heterocyclic compounds, such as the synthesis of mold penicillin antibiotics, Pyrazine compounds and other drugs and pesticides.

Method:
The preparation of 2-Pyrazinecarbonyl chloride is mainly obtained by reacting pyrazin-2-amine with acid chloride. The specific preparation method is as follows:
1. First, the pyrazin-2-amine is added to the organic solvent in which the acid chloride is dissolved.
2. Slowly add pyrazin-2-amine Dropwise and keep the temperature of the reaction system at -10 to 0°C.
3. After completion of the reaction, the reaction solution was washed with water and dried.
4. Finally, the 2-Pyrazinecarbonyl chloride product was obtained by distillation purification.

Safety Information:
2-Pyrazinecarbonyl chloride is an organic compound. The following safety precautions should be paid attention to when using it:
-The compound is irritating and corrosive, avoid contact with skin and eyes.
-Wear appropriate personal protective equipment during operation, including protective goggles, lab gloves and protective clothing.
-Maintain good ventilation during operation.
-Avoid storing or handling this compound with flammable substances as it can cause a fire or explosion.
-When using or storing, pay attention to comply with local laws and regulations.

Before using 2-Pyrazinecarbonyl chloride, please be sure to read the relevant safety information and operating instructions carefully, and take appropriate safety measures according to the specific situation.

Last Update：2024-04-09 21:01:54