Pyridine, 3-chloro-2-fluoro-
3-Chloro-2-fluoro-pyridine
CAS: 1480-64-4
Molecular Formula: C5H3ClFN
Pyridine, 3-chloro-2-fluoro- - Names and Identifiers
| Name | 3-Chloro-2-fluoro-pyridine |
| Synonyms | 3-CHLORO-2-FLUOROPYRIDINE 3-Chloro-2-fluoro-pyridine 2-Fluoro-3-chloro pyridine Pyridine, 3-chloro-2-fluoro- |
| CAS | 1480-64-4 |
| InChI | InChI=1/C5H3ClFN/c6-4-2-1-3-8-5(4)7/h1-3H |
| InChIKey | IHGMHTQDGNVKTA-UHFFFAOYSA-N |
Pyridine, 3-chloro-2-fluoro- - Physico-chemical Properties
| Molecular Formula | C5H3ClFN |
| Molar Mass | 131.54 |
| Density | 1.33 |
| Boling Point | 162℃ |
| Flash Point | 52°(126°F) |
| Vapor Presure | 2.86mmHg at 25°C |
| Appearance | clear liquid |
| Color | Colorless to Almost colorless |
| pKa | -2.71±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.5030 |
Pyridine, 3-chloro-2-fluoro- - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes R34 - Causes burns R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R10 - Flammable |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | 2924 |
| HS Code | 29333990 |
| Hazard Class | 3 |
| Packing Group | III |
Pyridine, 3-chloro-2-fluoro- - Reference Information
| Application | 3-chloro-2-fluoropyridine is an organic intermediate, it can be obtained from 2-nitro-3-chloropyridine or 2, 3-dichloropyridine by fluoro in one step. 3-chloro-2-fluoropyridine can be used for the preparation of 3-chloro-2 hydrazopyridine. 3-chloro-2-hydrazinopyridine is an important intermediate for the synthesis of a new type of receiver insecticide, chlorfenamide and cyanuramide. |
| preparation | cesium fluoride (2.053g,13.51 mmol) was added to 2, 3-dichloropyridine (1.00g,6.76 mmol) in dimethyl sulfoxide (33.8 ml). The mixture was stirred at 110°C for 20 h in air. The mixture was quenched with water at room temperature. The reaction mixture was extracted with EtOAc. The organic layer was separated. The organic layer was washed with water and brine. The organic layer was dried over anhydrous sodium sulfate. The organic layer was concentrated in vacuo. The residue was purified by column chromatography (silica gel, eluting with ethyl acetate in hexane) to give 3-chloro-2-fluoropyridine. |
Last Update：2024-04-09 20:48:19
