RAF265 (CHIR-265)

Name	RAF265 (CHIR-265)
Synonyms	RAF265 CS-1852 RAF265(CHIR-265) RAF265 (CHIR-265) CHIR-265 or RAF265 1-Methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine 1-methyl-5-(2-(5-(trifluoromethyl)-1H-imidazol-2-yl)pyridin-4-yloxy)-N-(4-(trifluoromethyl)phenyl)-1H-benzo[d]imidazol-2-amine RAF 265 1-Methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine 1-Methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine RAF265 (CHIR-265)
CAS	927880-90-8

Molecular Formula	C24H16F6N6O
Molar Mass	518.41
Density	1.50
Boling Point	667.6±65.0 °C(Predicted)
pKa	9.07±0.27(Predicted)
Storage Condition	-20℃
Sensitive	Light Sensitive
Use	RAF265 (CHIR-265) is a highly selective B- Raf and VEGFR2 inhibitor with IC50 of 3-60 nM, which also inhibits VEGFR2 phosphorylation, EC50 of 30 nM,Phase 2.
In vitro study	RAF265 is a potent novel BRAF/VEGFR-2 inhibitor that acts on A375M(RAF265 has significant activity against BRAF in HT29 and MDAMB231 cells, with an IC20 of 1 to 3 μm, the IC50 is 5 to 10 μm. Treatment of BRAF mutant cell lines with concentrations of 1 to 10 μm RAF265 reduced MEK phosphorylation. Treatment of non-BRAF mutant cell lines with 1 μm RAF265 increased MEK phosphorylation, which was reversed when RAF265 concentrations reached 5 μm. The toxicity of RAF265 on HCT116 cell line was enhanced by the addition of RAD001. Treatment with RAF265 reduced pERK levels in a dose-dependent manner, and treatment with 0.5 mM RAF265 for 2 hours completely blocked phase G2-M progression, resulting in G2-M cells. Inhibition of expression of RAF265
In vivo study	RAF265 inhibited the accumulation of FDG in A375M tumor. RAF265 is a novel, oral, small-molecule BRAF kinase and VEGFR-2 inhibitor that acts on mutant BRAF tumor models with potent anticancer activity. In the study of human xenografts, RAF265 is highly effective in mutant BRAF human xenografts and some wild-type BRAF models.

Last Update：2024-01-02 23:10:35

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Product Name: RAF265 (CHIR-265) Visit Supplier Webpage Request for quotation
CAS: 927880-90-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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RAF265 (CHIR-265)

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