RARECHEM AH PB 0215
2-Fluorophenylboronic acid
CAS: 1993-03-9
Molecular Formula: C6H6BFO2
RARECHEM AH PB 0215 - Names and Identifiers
| Name | 2-Fluorophenylboronic acid |
| Synonyms | AKOS BRN-0104 RARECHEM AH PB 0215 2-Fluorophenylboroni o-Fluorphenylborsaeure O-FLUORPHENYLBORSAEURE 2-Flurorphenylboronic acid O-FLUOROPHENYLBORONIC ACID 2-Fluorophenylboronic acid 2-FLUOROBENZENEBORONIC ACID o-fluoro-benzeneboronic acid BORONIC ACID, B-(2-FLUOROPHENYL)- Boronic acid, B-(2-fluorophenyl)- |
| CAS | 1993-03-9 |
| EINECS | 671-858-7 |
| InChI | InChI=1/C6H6BFO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4,9-10H |
RARECHEM AH PB 0215 - Physico-chemical Properties
| Molecular Formula | C6H6BFO2 |
| Molar Mass | 139.92 |
| Density | 1.24±0.1 g/cm3(Predicted) |
| Melting Point | 101-110 °C (lit.) |
| Boling Point | 267.8±42.0 °C(Predicted) |
| Flash Point | 115.8°C |
| Solubility | soluble in Methanol |
| Vapor Presure | 0.00395mmHg at 25°C |
| Appearance | White to yellow crystalline powder |
| Color | White to light yellow |
| BRN | 3030413 |
| pKa | 8.32±0.58(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.508 |
| MDL | MFCD00674013 |
RARECHEM AH PB 0215 - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed |
| Safety Description | S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S27 - Take off immediately all contaminated clothing. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29319090 |
| Hazard Class | IRRITANT |
RARECHEM AH PB 0215 - Reference Information
| Application status | 2-fluorophenylboronic acid belongs to fluorophenylboronic acid and its derivatives. 2-Fluorophenylboronic acid Because the atomic radius of the fluorine atom and the hydrogen atom is similar, when the hydrogen atom in the molecule is replaced by the fluorine atom, it will not cause a significant change in the three-dimensional configuration of the molecule. However, due to the strong electron absorption of fluorine atoms, the electronic properties of the original molecules often change greatly, so that fluorophenylboronic acid has good stability and greater dielectric anisotropy. In recent years, it has played a very important role in organic synthesis, biomedicine, pesticides and materials science, especially in liquid crystal display materials. |
| preparation | 14kg(22.9mol) of o-fluorobromobenzene and THF20L were sequentially added into a 50L reactor under the protection of nitrogen, and the temperature was reduced to -70 ℃. Add n-BuLi6.8kg dropwise below -70 ℃, and stir below -70 ℃ for 0.5 hours after dripping. Add 4.75kg of triisopropyl borate drop below -70 ℃, and naturally return to temperature overnight after drop. Pour 20L(1N) dilute hydrochloric acid, separate the liquid, and extract the aqueous phase once with EA10L. The organic phase is combined, washed once with saturated salt water 10L, anhydrous sodium sulfate is dried, filtered and concentrated to obtain 22.4kg of compound 2-fluorobenzene boronic acid with a yield of 85%. |
Last Update：2024-04-10 22:29:15
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