RARECHEM AL BF 0232

RARECHEM AL BF 0232 - Names and Identifiers

Name	Methyl 3-chloro-4-hydroxybenzoate
Synonyms	RARECHEM AL BF 0232 Methyl 3-chloro-4-hydroxybenzoate METHYL 3-CHLORO-4-HYDROXYBENZOATE METHYL-4-HYDROXY-3-CHLOROBENZOATE 3-chloro-4-hydroxy-2-methylbenzoate 3-CHLORO-4-HYDROXYBENZOIC ACID METHYL ESTER 4-HYDROXY-3-CHLOROBENZOIC ACID METHYL ESTER 3-Chloro-4-hydroxybenzoic acid methyl ester
CAS	3964-57-6
EINECS	223-573-0
InChI	InChI=1/C8H7ClO3/c1-12-8(11)5-2-3-7(10)6(9)4-5/h2-4,10H,1H3

RARECHEM AL BF 0232 - Physico-chemical Properties

Molecular Formula	C8H7ClO3
Molar Mass	186.59
Density	1.354±0.06 g/cm3(Predicted)
Melting Point	108-110°C
Boling Point	284.9±20.0 °C(Predicted)
Flash Point	126.1°C
Vapor Presure	0.00168mmHg at 25°C
BRN	2641291
pKa	6.89±0.18(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.564
MDL	MFCD00016418

RARECHEM AL BF 0232 - Risk and Safety

Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes.

RARECHEM AL BF 0232 - Reference Information

Application

Methyl 3-chloro-4-hydroxybenzoate is an organic intermediate, which can be obtained by one-step esterification of 3-chloro-4-hydroxybenzoic acid. It is an organic synthesis intermediate and a pharmaceutical intermediate, which can be used in laboratory research and development processes and chemical production processes.

Preparation

Sulfuric acid (3mL, 56.3mmol) was added to a solution of 3-chloro-4-hydroxy-benzoic acid (1.0g,5.8mmol) in methanol (30mL), and the mixture was stirred at 60°C for 12 hours. The reaction mixture was cooled to room temperature and methanol was removed in a vacuum. The residue was partitioned between saturated K2CO3 solution and ethyl acetate (3 × 30mL), dried, filtered, and concentrated in vacuum to give a white solid methyl 3-chloro-4-hydroxybenzoate (0.9g,83%). ESI-MS m/z theoretical value: 186.5, measured value: 187.5(M +1)+; Retention time: 1.17 minutes (running for 3 minutes).

Last Update：2024-04-09 21:11:58