RARECHEM AL BO 0356
2-chloro-5-(trifluoromethyl)benzoic acid
CAS: 657-06-7
Molecular Formula: C8H4ClF3O2
RARECHEM AL BO 0356 - Names and Identifiers
| Name | 2-chloro-5-(trifluoromethyl)benzoic acid |
| Synonyms | RARECHEM AL BO 0356 TIMTEC-BB SBB003328 2-Chloro-5-trifluoromethylbenzoic acid 2-CHLORO-5-(TRIFLUOROMETHYL)BENZOIC ACID 2-chloro-5-(trifluoromethyl)benzoic acid 2-Chloro-5-(trifluoromethyl)benzoic acid 2-chloro-5-(trifluoromethoxy)benzoic acid Benzoic acid, 2-chloro-5-(trifluoromethyl)- 3-Carboxy-4-chlorobenzotrifluoride, 6-Chloro-alpha,alpha,alpha-trifluoro-m-toluic acid |
| CAS | 657-06-7 |
| InChI | InChI=1/C8H4ClF3O2/c9-6-2-1-4(8(10,11)12)3-5(6)7(13)14/h1-3H,(H,13,14) |
| InChIKey | WLXRKCGYQAKHSJ-UHFFFAOYSA-N |
RARECHEM AL BO 0356 - Physico-chemical Properties
| Molecular Formula | C8H4ClF3O2 |
| Molar Mass | 224.56 |
| Density | 1.523±0.06 g/cm3(Predicted) |
| Melting Point | 93-96 °C (lit.) |
| Boling Point | 270.4±40.0 °C(Predicted) |
| Flash Point | 117.3°C |
| Vapor Presure | 0.00338mmHg at 25°C |
| pKa | 2.45±0.25(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.495 |
RARECHEM AL BO 0356 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S37 - Wear suitable gloves. |
| WGK Germany | 3 |
| HS Code | 29163990 |
| Hazard Class | IRRITANT |
RARECHEM AL BO 0356 - Reference Information
| Use | 2-chloro-5-(trifluoromethyl) benzoic acid is an important intermediate of a new type of drug for the treatment of diabetes. In addition, it can also be used to synthesize heat shock protein inducers and non-steroidal anti-inflammatory drugs. As an important pharmaceutical intermediate, 2-chloro-5-(trifluoromethyl) benzoic acid also has an important application prospect in the research and development of new drugs. |
| preparation | weigh the compounds p-chlorotrifluoromethylbenzene 18.1g(0.1mol) and tetramethylethylenediamine 11.6g(0.1mol) dissolved in 150ml of anhydrous tetrahydrofuran, and cool the reaction mixture to -75 ℃ with dry ice acetone bath. the reaction system is vacuumed for nitrogen protection. Under the protection of nitrogen, 77.0ml(0.1mol) of tert-butyl lithium (1.3M n-hexane solution) is extracted and placed in a constant pressure drop funnel, and then slowly added into the reaction system. When dropping, the reaction temperature does not exceed -70 ℃. After dropping, the reaction continues to stir for 1 hour, slowly pour the reaction solution on the surface of 50g of dry ice, continue to stir for 30 minutes, wait until the dry ice is volatilized, adjust the pH value to 4 with 30ml of 6N hydrochloric acid, continue to stir the reaction post-treatment solution at 5-10 ℃ for 5-6 hours, light yellow solid will be precipitated, filtered, washed with water, and vacuum dried at 40 ℃ to obtain 21.7g of light yellow crude product. Add 21.7g of crude product to 100ml of n-hexane solution, heat and reflux for 30 minutes, cool to room temperature, precipitate solids, and filter to obtain 20.61g of white crystalline refined product with a yield of 92%. |
Last Update：2024-04-09 20:49:11
Supplier List
Spot supply
Product Name: 2-Chloro-5-trifluoromethylbenzoic acid Visit Supplier Webpage Request for quotationCAS: 657-06-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: 2-Chloro-5-(trifluoromethyl)benzoic acid Visit Supplier Webpage Request for quotationCAS: 657-06-7
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: 2-Chloro-5-(Trifluoromethyl)Benzoic Acid Visit Supplier Webpage Request for quotation
CAS: 657-06-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 657-06-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Product Name: 2-chloro-5-(trifluoromethyl)benzoic acid Request for quotation
CAS: 657-06-7
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: +8613651600618
WhatsApp: +8613651600618
CAS: 657-06-7
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: +8613651600618
WhatsApp: +8613651600618
Spot supply
Product Name: 2-Chloro-5-trifluoromethylbenzoic acid Visit Supplier Webpage Request for quotationCAS: 657-06-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: 2-Chloro-5-(trifluoromethyl)benzoic acid Visit Supplier Webpage Request for quotationCAS: 657-06-7
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: 2-Chloro-5-(Trifluoromethyl)Benzoic Acid Visit Supplier Webpage Request for quotation
CAS: 657-06-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 657-06-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Product Name: 2-chloro-5-(trifluoromethyl)benzoic acid Request for quotation
CAS: 657-06-7
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: +8613651600618
WhatsApp: +8613651600618
CAS: 657-06-7
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: +8613651600618
WhatsApp: +8613651600618
View History