REVERSINE
Reversine
CAS: 656820-32-5
Molecular Formula: C21H27N7O
REVERSINE - Names and Identifiers
REVERSINE - Physico-chemical Properties
| Molecular Formula | C21H27N7O |
| Molar Mass | 393.49 |
| Density | 1.343±0.06 g/cm3(Predicted) |
| Melting Point | 305℃ (decomposition) |
| Boling Point | 736.4±70.0 °C(Predicted) |
| Solubility | DMSO: soluble7 mg/mL;H2O: insoluble |
| Appearance | solid |
| Color | Off-white |
| pKa | 10.51±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months |
| MDL | MFCD07784513 |
| Use | Reversine is a synthetic purine analog that can inhibit Aurora A/B/C with IC50 of 150 to 500 nM. |
| In vitro study | Reversine induces myogenic lineage-committed cells to become multipotent mesenchymal progenitor cells, which proliferates and redifferentiates into bone and fat cells. Reversine, as an A3 adenosine receptor antagonist, competitively inhibits forskolin-stimulated cAMP production in stably transfected Chinese hamster ovary (CHO) cells. Reversine inhibits the phosphorylation of a well-known Aurora target, histone H3 in HCT116 cells. Moreover, Reversine potently blocks proliferation of multiple tumor cell types, and induces cell death. In primary human tumor samples, Reversine also inhibits colony formation of leukemic cells. When treated in combination, reversine and aspirin synergistically inhibit growth of cervical cancer cells and induce cell apoptosis. |
| In vivo study | In mice inoculated with U14 tumors, Reversine (10 mg/kg i.p.) and aspirin cause more reduced tumor weight and tumor volume when compared with the control agents. |
REVERSINE - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| WGK Germany | 3 |
REVERSINE - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.541 ml | 12.707 ml | 25.414 ml |
| 5 mM | 0.508 ml | 2.541 ml | 5.083 ml |
| 10 mM | 0.254 ml | 1.271 ml | 2.541 ml |
| 5 mM | 0.051 ml | 0.254 ml | 0.508 ml |
Last Update：2024-01-02 23:10:35
REVERSINE - Reference Information
| biological activity | relapsin is a potent human A3 adenosine receptor antagonist with a Ki of 0.66 μm, it is also A pan aurora A/B/C kinase inhibitor with an IC50 of 12 nM/13 nM/20 nM, respectively. It is also used for stem cell differentiation. |
Last Update：2024-04-09 20:49:11
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Spot supply
Product Name: Reversine Visit Supplier Webpage Request for quotationCAS: 656820-32-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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