RS 25233-197

Name	Palonosetron
Synonyms	2-Qhbiqo RS-25233-197 RS-25233-198 RS 25259-198 RS 25259-197 RS-25259-198 Palonosetron RS 25233-197 Rs 25233-197 Palonosetron [inn] Palonosetron [INN] (S)-2-((S)-quinuclidin-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one 2-(1-Azabicyclo(2.2.2)oct-3-yl)-2,3,3A,4,5,6-hexahydro-1H-benz(de)isoquinolin-1-one 2-(1-Azabicyclo(2.2.2)oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz(de)isoquinolin-1-one (S-(R,R))-2-(1-Azabicyclo(2.2.2)oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz(de)isoquinolin-1-one (S-(R,R))-2-(1-Azabicyclo(2.2.2)oct-3-yl)-2,3,3A,4,5,6-hexahydro-1H-benz(de)isoquinolin-1-one 1H-Benz[de]isoquinolin-1-one, 2-(3S)-1-azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-, (3aS)- 1H-Benz(de)isoquinolin-1-one, 2-(1-azabicyclo(2.2.2)oct-3-yl)-2,3,3A,4,5,6-hexahydro-, (S-(R,R))- 1H-Benz(de)isoquinolin-1-one, 2-(1-azabicyclo(2.2.2)oct-3-yl)-2,3,3a,4,5,6-hexahydro-, (S-(R,R))-
CAS	135729-61-2
EINECS	1312995-182-4
InChI	InChI=1/C19H24N2O/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20/h2,4,6,13,15,17H,1,3,5,7-12H2/t15-,17+/m0/s1

Molecular Formula	C19H24N2O
Molar Mass	296.41
Density	1.24±0.1 g/cm3(Predicted)
Melting Point	87-88°
Boling Point	470.4±45.0 °C(Predicted)
Specific Rotation(α)	D -136° (c = 0.25 in chloroform)
pKa	9.77±0.33(Predicted)
Storage Condition	-20℃
In vitro study	Palonosetron is a 5-HT3 receptor antagonist with a high binding affinity for this receptor and only very weak or no binding affinity for other receptors.
In vivo study	Palonosetron has a longer half-life and higher binding affinity than first generation 5-HT3 receptor antagonists. After administration of intravenous injections to healthy volunteers and cancer patients, the blood concentration of palonosetron decreased from the initial to the later slow elimination from the body. The mean maximum plasma concentration and the area under the concentration-time curve are generally dose proportional (linear) over the 0.3-90 μg/kg dose range. Palonosetron has a volume of distribution of about 8.3±2.5 L/kg and a binding rate to plasma proteins of 62%. It is mainly eliminated from the body through renal excretion and metabolic pathways, and the average terminal elimination half-life is about 40 hours.

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Product Name: Palonosetron Visit Supplier Webpage Request for quotation
CAS: 135729-61-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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RS 25233-197

RS 25233-197 Request for Quotation