Raddeanin A
3-{[6-deoxyhexopyranosyl-(1->2)hexopyranosyl-(1->2)pentopyranosyl]oxy}olean-12-en-28-oic acid
CAS: 89412-79-3
Molecular Formula: C47H76O16
Raddeanin A - Names and Identifiers
| Name | 3-{[6-deoxyhexopyranosyl-(1->2)hexopyranosyl-(1->2)pentopyranosyl]oxy}olean-12-en-28-oic acid |
| Synonyms | Raddeanin A Raddeanin R3 anemodeanin A Raddeanoside R3 Raddeanin(Anemodeanin) A 2)-a-L-arabinopyranosyl)oxy]-, (3b)- (3beta)-3-[(O-6-Deoxy-alpha-L-mannopyranosyl-(1-2)-O-beta-D-glucopyranosyl-(1-2)-alpha-L-arabinopyranosyl)oxy]olean-12-en-28-oic acid |
| CAS | 89412-79-3 |
| InChI | InChI=1/C47H76O16/c1-22-30(50)33(53)35(55)38(59-22)62-37-34(54)32(52)26(20-48)60-40(37)63-36-31(51)25(49)21-58-39(36)61-29-12-13-44(6)27(43(29,4)5)11-14-46(8)28(44)10-9-23-24-19-42(2,3)15-17-47(24,41(56)57)18-16-45(23,46)7/h9,22,24-40,48-55H,10-21H2,1-8H3,(H,56,57)/t22-,24-,25-,26+,27-,28+,29-,30-,31-,32+,33+,34-,35+,36+,37+,38-,39-,40-,44-,45+,46+,47-/m0/s1 |
Raddeanin A - Physico-chemical Properties
| Molecular Formula | C47H76O16 |
| Molar Mass | 897.1 |
| Density | 1.36 |
| Melting Point | 242～244℃ |
| Boling Point | 967.2±65.0 °C(Predicted) |
| Specific Rotation(α) | +37゜（Ethanol）；+36.8゜（c=1.9,Ethanol） |
| Flash Point | 276.2°C |
| Solubility | Soluble in water, methanol, ethanol, insoluble in acetone, ethyl acetate and other low polar solvents. |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White powder |
| Color | White to Off-White |
| pKa | 4?+-.0.70(Predicted) |
| Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| Refractive Index | 1.61 |
| MDL | MFCD10566637 |
| Physical and Chemical Properties | Dissolved in water, derived from the tips of the two heads, mostly raddeana Regel rhizomes Anemone by anemone (Cynus japonicus). |
Raddeanin A - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29329990 |
Raddeanin A - Reference
| Reference Show more | 1. Wang Yu, Jiang Xiubo, Han bean, Zhu Zhiming, Song Chang Qin, Zhao Ang, Zhang Qi, Liu Chang Hui, Ma Bo. Effects of Rhizoma cyperae A on proliferation, apoptosis, migration and invasion of human colon cancer cell line HCT-116 [J]. Chinese new medicines and clinical pharmacology, 2018,29(02):123-130. 2. Tang Jun Zhang Jie Sun Wei Zhao Ang Zhu Zhiming Bao Xiao Wen Zhang Ming Ya Ma Bo. Simultaneous determination of Sanguisorba officinalis saponin Ⅰ and Sanguisorba officinalis saponin Ⅱ in rat plasma by LC-MS/MS and its pharmacokinetics [J]. Bioprocess 2019 17(05):536-541. 3. Li Hongbo, Huang Rui, general, Zhong Zhendong. Protective Mechanism of Rhizoma Cyperus A on hepatic ischemia-reperfusion injury in rats [J]. Laboratory animal and comparative medicine, 2021,41(01):55-60 65. 4. [IF = 4.858] Zhuoying Wang et al."attenuation of STAT3 phosphorylation promotes Apoptosis and chemosensitivity in Human osteosarcoma Induced by raddeanin A." Int J Biol Sci. 2019; 15(3): 668-679 5. [IF = 4.486] Hongyan Xia et al."Raddeanin A down‐regulates androgen receptor and its splice variants in prostate cancer."J Cell Mol Med. 2019 May;23(5):3656-3664 6. [IF=3.585] Bo Ma et al."Raddeanin A, a natural triterpenoid saponin compound, exerts anticancer effect on human osteosarcoma via the ROS/JNK and NF-κB signal pathway."Toxicol Appl Pharm. 2018 Aug;353:87 7. [IF=3.448] Yu Wang et al."Raddeanin A inhibits growth and induces apoptosis in human colorectal cancer through downregulating the Wnt/β-catenin and NF-κB signaling pathway."Life Sci. 2018 Aug;207:532 8. [IF=4.966] Zhuoying Wang et al."Antitumor activity of Raddeanin A is mediated by Jun amino‐terminal kinase activation and signal transducer and activator of transcription 3 inhibition in human osteosarcoma."Cancer Sci. 2019 May;110(5):1746-1759 9. [IF=3.269] Zhiyu Li et al."1α,25(OH)2D3(VD3) promotes Raddeanin A- induced anti-proliferative effects on HeLa cell apoptosis and autophagy through negative regulation of HPV18E6-E7/PD-L1/VDR axis."Bioengineered. 2022;13(1):357-369 |
Raddeanin A - Reference Information
| biological activity | Raddeanin A is A natural triterpene saponin in Rhizoma cyperi, which has anti-cancer activity. Raddeanin A exerts anti-cancer effects on human osteosarcoma through ROS/JNK and NF-Δb signaling pathways. |
| Target | Value |
| Use | Rhizoma cynanchae A is A triterpene saponin in two tip plants, which has good anti-tumor activity in vitro. |
Last Update：2024-04-09 21:32:09
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