Rhynchophylline 76-66-4
rhynchophylline
CAS: 76-66-4
Molecular Formula: C22H28N2O4
Rhynchophylline 76-66-4 - Names and Identifiers
| Name | rhynchophylline |
| Synonyms | mitrinermin MITRINERMINE rhynchophyllin RHYNCHOPHYLLINE rhynchophylline Rhyncholphylline RHYNCHOLPHYLLINE Hook vine extract 16e,20-alpha)-(7-bet Rhynchophylline 76-66-4 methyl (16Z)-16-(methoxymethylidene)-2-oxocorynoxan-17-oate methyl (3xi,16E,20alpha)-16-(methoxymethylidene)-2-oxocorynoxan-17-oate methyl (3xi,16Z,20alpha)-16-(methoxymethylidene)-2-oxocorynoxan-17-oate methyl (7beta,16E,20alpha)-16-(methoxymethylidene)-2-oxocorynoxan-17-oate |
| CAS | 76-66-4 |
| InChI | InChI=1/C22H28N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h5-8,13-15,19H,4,9-12H2,1-3H3,(H,23,26)/b16-13-/t14-,15-,19?,22?/m0/s1 |
| InChIKey | DAXYUDFNWXHGBE-QCJVZUPCSA-N |
Rhynchophylline 76-66-4 - Physico-chemical Properties
| Molecular Formula | C22H28N2O4 |
| Molar Mass | 384.47 |
| Density | 1.23 |
| Melting Point | 216°; mp 197-199° (Ban et al., loc. cit.) |
| Boling Point | 560.8±50.0 °C(Predicted) |
| Specific Rotation(α) | D13 -14.7° (c = 2.5 in chloroform) |
| Flash Point | 293°C |
| Solubility | Soluble in chloroform, acetone, ethanol, benzene, slightly soluble in ether and ethyl acetate, almost insoluble in petroleum ether. |
| Vapor Presure | 1.32E-12mmHg at 25°C |
| Appearance | White crystal |
| Color | White to Off-White |
| Maximum wavelength(λmax) | ['247nm(lit.)'] |
| Merck | 14,8197 |
| pKa | 6.4(at 25℃) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Refractive Index | 1.596 |
| MDL | MFCD00221748 |
| Physical and Chemical Properties | Soluble in chloroform, acetone, ethanol, benzene, ether-soluble and ethyl acetate, almost insoluble in petroleum ether. From Uncaria rhynchopilla (Miq.) Hook branch |
Rhynchophylline 76-66-4 - Risk and Safety
| RTECS | GN1600000 |
| HS Code | 29399990 |
Rhynchophylline 76-66-4 - Reference
| Reference Show more | 1. Lou Huawei, Li Lingjun, Li Ji. Study on the absorption kinetics of rhynchophylline and isorhynchophylline in the isolated small intestine of rats [J]. Chinese Journal of Experimental prescriptions, 2013, 19(7):150-153. 2. Li Ji, Li Lingjun, Lou Huawei. In vivo intestinal absorption kinetics of rhynchophylline and isorhynchophylline in Tiangou Jiangya capsule in rats [J]. Chinese Journal of Experimental prescriptions, 2013, 19(6):167-170. 3. Yan Rui, Li Lingjun, Li Shun. Pharmacokinetics of rhynchophylline in Tiangou Jiangya capsule in rats [J]. Journal of Shandong University of Traditional Chinese Medicine, 2014, 000(003):257-259. 4. Huang Zhen, Zhou Honglei, Li Yunlun, etc. Study on the evaluation system of the fingerprint of the tablet [J]. Liaoning Journal of Traditional Chinese Medicine, 2014, 041(006):1251-1253. 5. Xu Youwei, Huang Zhen, Zhou Honglei, etc. Study on the quality control of tengsulforaphane tablets [J]. Chinese new drugs and clinical pharmacology, 2015, 026(005):690-694. 6. Zhao Xingye, Wang Yinhui, Cui Xiaoge, et al. Preparation and formulation optimization of rhynchophylline double-layer osmotic pump controlled release tablets [J]. Chinese patent medicine, 2020, v.42(05):17-21. 7. Suzhen Li, Zhenxiang Tang, Wei Wu. Preparation and release of rhynchophylline liposomes [J]. Chinese Journal of Traditional Chinese Medicine, 2013, 028(012):3730-3732. 8. Wang, Mei, Sun, gang. Determination of rhynchophylline and isorhynchophylline in Anle tablets by HPLC [J]. Chinese drug Standard 2017(4). 9. Zhang Yuan-yuan, Zeng Hui-ting, Chen Chao et al. Separation and determination of rhynchophylline and isorhynchophylline in Uncaria by HPLC with ionic liquid as mobile phase additive [J]. China pharmacy 2019 v.30;No.663(21):77-82. 10. Liu Ming, Wang Huisen, Li Shen. Study on quality standard of Chunhua Jiangya tablets [J]. Northwest Pharmaceutical Journal, 2020, v.35(03):9-12. 11. Fan Hui, Tian Yuan. Optimization of ethanol extraction process of Tianma Anshen granules by orthogonal test [J]. Chinese Journal of Experimental prescriptions, 2015, 21(7):21-23. 12. Guo Xiaomin, Huang Baoyuan, Zeng Chang Qing. Screening of Uncaria alkaloid extract and its monomer to reverse drug resistance activity of HepG2/ADM cells [J]. Journal of Guangdong Pharmaceutical College, 2018, 034(004):447-451. 13. Fan Sufang, Ma Junmei, Liu Min, et al. Determination of 15 toxic alkaloids in foods by high performance liquid chromatography-tandem mass spectrometry [J]. Food Science, 2018, 39(22):290-295. 14. Deng Xiangtao, Zhang Wenzhou, Zhang Zhiqiang. Preparation, optimization and in vitro release evaluation of rhynchophylline nanosuspension sustained-release tablets [J]. Chinese herbal medicine, 2020,51(20):5128-5136. 15. [IF = 3.935] Shuanglu Xie et al."Systematic identification and quantification of tectyclic monoterpenoid oxindole alkaloids in Uncaria rhynchophylla and their fragmentations in Q-TOF-MS spectra." J Pharmaceut Biomed. 2013 Jul;81-82:56 16. [IF = 1.908] Xin Wang et al."Stereoselective pharmacokinetic study of rhynchophylline and isorhynchophylline epimers in rat plasma by liquid chromatography-tandem mass spectrometry."Xenobiotica. 2017;47(6):479-487 17. [IF=4.759] Keyu Feng et al."Configuration of the ion exchange chromatography, hydrophilic interaction chromatography, and reversed-phase chromatography as off-line three-dimensional chromatography coupled with high-resolution quadrupole-Orbitrap mass spectrometry fo 18. [IF=3.996] Jiang Pan et al."Neuroprotective Effects of Rhynchophylline Against Aβ1-42-Induced Oxidative Stress, Neurodegeneration, and Memory Impairment Via Nrf2-ARE Activation."Neurochem Res. 2021 Sep;46(9):2439-2450 19. [IF=3.935] Wenwen Huang et al."Rapid discovery of potentially vasodilative compounds from Uncaria by UHPLC/Q-Orbitrap-MS based metabolomics and correlation analysis."J Pharmaceut Biomed. 2021 Nov;206:114384 20. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950 21. [IF=2.649] Long Hongyan et al."Rhynchophyllin attenuates neuroinflammation in Tourette syndrome rats via JAK2/STAT3 and NF‐κB pathways."Environ Toxicol. 2019 Oct;34(10):1114-1120 22. [IF=6.529] Lingling Xie et al."Uncaria Rhynchophylla attenuates angiotensin Ⅱ-induced myocardial fibrosis via suppression of the RhoA/ROCK1 pathway."Biomed Pharmacother. 2022 Feb;146:112607 23. [IF=5.811] Liu Jiao et al."Rhynchophylline Regulates Calcium Homeostasis by Antagonizing Ryanodine Receptor 2 Phosphorylation to Improve Diabetic Cardiomyopathy."Frontiers in Pharmacology. 2022 Apr;0:1375 |
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