Rivaroxaban Impurity 121

Rivaroxaban Impurity 121 - Names and Identifiers

Name	2,2'-(2-Hydroxypropane-1,3-diyl)bis(2H-isoindole-1,3-dione)
Synonyms	Rivaroxaban Impurity 121 Phthalimide, N,N'-(2-hydroxytrimethylene)di 2,2'-(2-Hydroxypropane-1,3-diyl)bis(isoindoline-1,3-dione) 2,2'-(2-Hydroxypropane-1,3-diyl)bis(2H-isoindole-1,3-dione) 2,2'-(2-hydroxypropane-1,3-diyl)bis(isoindoline-1,3-dione)? (Rivaroxaban Impurity)
CAS	73825-95-3

Rivaroxaban Impurity 121 - Physico-chemical Properties

Molecular Formula	C19H14N2O5
Molar Mass	350.32
Density	1.502±0.06 g/cm3(Predicted)
Melting Point	203 °C
Boling Point	580.4±45.0 °C(Predicted)
pKa	13.62±0.20(Predicted)

Rivaroxaban Impurity 121 - Introduction

2,2 '-(2-Hydroxypropane-1,3-diyl)bis(2H-isoindole-1,3-dione) is an organic compound often referred to simply as HPMDI. The following is a description of its nature, use, preparation and safety information:

Nature:
HPMDI is a yellow to brown solid with a molecular formula of C20H12N2O4 and a relative molecular mass of 344.32. It is relatively stable at room temperature and soluble in some organic solvents. The structure of HPMDI consists of two phthalimide (isoindole-1,3-dione) molecules bridged by 2-propanol.

Use:
HPMDI is an important organic synthesis intermediate, widely used in the synthesis of high-performance polyurethane, polysulfide and other polymers. It can form a polymer by reacting with polyether or Polyether alcohol, and has excellent mechanical properties, heat resistance and chemical resistance, so it has a wide range of applications in the fields of automobiles, construction, electronics and textiles.

Method:
The preparation of HPMDI is usually obtained by reacting phthalimide with 2-propanol under appropriate reaction conditions. The general preparation method includes the reaction of phthalimide and 2-propanol in a solvent, followed by crystallization and purification steps to obtain a pure HPMDI product.

Safety Information:
HPMDI needs to be handled under appropriate experimental conditions and operational measures. It can cause irritation and damage to the skin, eyes and respiratory system. Therefore, appropriate personal protective equipment such as gloves, protective glasses and protective masks should be worn when touching or operating HPMDI. In addition, it is necessary to operate in a well-ventilated laboratory or work area, and follow relevant safety operating procedures and precautions.

It should be noted that the above content is for reference only. Specific Properties, Uses, methods and safety information also need to refer to specific laboratory manuals, chemical safety data sheets and related literature. When using HPMDI or any chemicals, please be careful and under the guidance of professionals.

Last Update：2024-04-10 22:29:15