Ro 48-8071 fumarate salt
Ro 48-8071 fumarate
CAS: 189197-69-1
Molecular Formula: C23H27BrFNO2.C4H4O4
Ro 48-8071 fumarate salt - Names and Identifiers
Ro 48-8071 fumarate salt - Physico-chemical Properties
| Molecular Formula | C23H27BrFNO2.C4H4O4 |
| Molar Mass | 564.45 |
| Melting Point | 90-92.7°C |
| Solubility | DMSO: ≥ 55 mg/mL |
| Appearance | solid |
| Color | white |
| Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
| In vitro study | In HepG2 cells, Ro 48-8071 reduces cholesterol synthesis dose dependently with an IC 50 value of appr 1.5 nM. Ro 48-8071 (10 μM) significantly reduces the viability of PC-3 prostate cancer cells, but not normal prostate cells. Ro 48-8071 (10-30 μM) induces apoptosis of both LNCaP and C4-2 cell lines in a dose-dependent manner. And castration-resistant PC-3 and DU145 cells also demonstrate significant levels of apoptosis following 24-hour treatment with Ro 48-8071. Ro 48-8071 (10-25 μM) reduces AR protein expression in a dose-dependent manner. Ro 48-8071 (0.1-1 μM) increases ERβ protein expression dose-dependently in both hormone-dependent LNCaP and castration-resistant PC-3 cells. Using mammalian cells engineered to express human ERα or ERβ protein, together with an ER-responsive luciferase promoter, Ro 48-8071 dose-dependently inhibits 17β-estradiol (E2)-induced ERα responsive luciferase activity (IC 50 , appr 10 µM), under conditions that are non-toxic to the cells. |
| In vivo study | Ro 48-8071 lowers LDL-C maximally appr 60% at 150 μmol/kg per day, with no further reduction up to 300 μmol/kg per day, leaving HDL-C unchanged at all doses in hamsters. Ro 48-8071 (≥00 μmol/kg per day) increases the amount of MOS in liver of hamsters. Ro 48-8071 (300 μmol/kg per day) remarkedly and significantly reduces VLDL secretion of hamsters. Ro 48-8071 (5 or 20 mg/kg) significantly reduces in vivo tumor growth in mice, without weight loss of the mice. Furthermore, Ro 48-8071 at a concentration of 20 mg/kg, completely eradicates two of the 12 tumors being monitored in the mice in the timeframe tested. Ro 48-8071 (20 mg/day/kg body weight) leads to a rapid and sustained inhibition (>50%) of cholesterol synthesis in the whole small intestine of BALB/c mice. Sterol synthesis is also reduced in the large intestine and stomach. |
Ro 48-8071 fumarate salt - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
Ro 48-8071 fumarate salt - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.772 ml | 8.858 ml | 17.717 ml |
| 5 mM | 0.354 ml | 1.772 ml | 3.543 ml |
| 10 mM | 0.177 ml | 0.886 ml | 1.772 ml |
| 5 mM | 0.035 ml | 0.177 ml | 0.354 ml |
Last Update：2024-01-02 23:10:35
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Product Name: Ro 48-8071 (fumarate) Visit Supplier Webpage Request for quotationCAS: 189197-69-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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