S-Adenosyl-L-methionine tosylate
S-Adenosyl-L-methionine tosylate
CAS: 71914-80-2
Molecular Formula: C15H23N6O5S.C7H7O3S
S-Adenosyl-L-methionine tosylate - Names and Identifiers
| Name | S-Adenosyl-L-methionine tosylate |
| Synonyms | SAM-E S-ADENOSYLMETHIONINE TOSYLATE S-ADENOSYL-L-METHIONINE (SAME) S-Adenosyl-L-methionine tosylate S-(5'-ADENOSYL)-L-METHIONINE P-TOLUENESULFONATE S-(5'-Adenosyl)-L-methionine p-toluenesulfonate S-(5'-ADENOSYL)-L-METHIONINE TOLUENE-4-SULFONATE S-(5''-Adenosyl)-L-methionine-4-toluenesulfonate S-(5'-Adenosyl)-L-methioninetoluene-4-sulfonate |
| CAS | 71914-80-2 |
S-Adenosyl-L-methionine tosylate - Physico-chemical Properties
| Molecular Formula | C15H23N6O5S.C7H7O3S |
| Molar Mass | 570.64 |
| Solubility | H2O: 0.1g/mL, clear |
| Storage Condition | −20°C |
| In vitro study | S-Adenosyl-L-methionine (Ademetionine) is involved in three main metabolic pathways: 1) methylation, as the principal source of methyl groups in the body; 2) transsulfuration, S-Adenosyl-L-methionine forms S-Adenosylhomocysteine (SAH) and then converted to homocysteine (Hcy) which can be converted to cystathionine then to cysteine and the sulfate (SO4) donated to other metabolic intermediates; and 3) aminopropylation, as S-Adenosyl-L-methionine plays an important role in the synthesis of polyamines which can eventually form and recycle methionine. In vitro studies using human articular chondrocytes have shown S-Adenosyl-L-methionine-induced increases in proteoglycan synthesis and proliferation rates in rabbits. |
| In vivo study | Mice lacking methionine adenosyltransferase 1a (Mat1a) have reduced hepatic S-Adenosyl-L-methionine levels and develop oxidative stress, steatohepatitis, and hepatocellular carcinoma (HCC). However, injury and HCC also occur if hepatic S-Adenosyl-L-methionine level is excessive chronically. Thus a normal hepatic S-Adenosyl-L-methionine level is necessary to maintain liver health and prevent injury and HCC. |
S-Adenosyl-L-methionine tosylate - Risk and Safety
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 1-10 |
S-Adenosyl-L-methionine tosylate - Reference Information
| biological activity | S-Adenosyl-L-methionine tosylate (S-Adenosyl meth tosylate) it is endogenously produced from methionine and ATP by the action of methionine adenosyltransferase and is an important orally active methyl donor. S-Adenosyl-L-methionine tosylate is a dietary supplement that has potent anti-depressant and analgesic effects and can be used in studies of liver disease and osteoarthritis. |
Last Update：2024-04-09 02:00:11
