S-EIT hemihydrate
2-Methyl-2-thiopseudourea sulfate
CAS: 867-44-7
Molecular Formula: C2H8N2O4S2
S-EIT hemihydrate - Names and Identifiers
S-EIT hemihydrate - Physico-chemical Properties
| Molecular Formula | C2H8N2O4S2 |
| Molar Mass | 188.23 |
| Density | 1.28 |
| Melting Point | 240-241 °C (dec.)(lit.) |
| Flash Point | 3℃ |
| Water Solubility | 260 g/L (20 ºC) |
| Appearance | Morphological Crystals or Crystalline Powder, color White |
| pKa | pK1:9.83(＋1) (25°C) |
| PH | 5.5 (260g/l, H2O, 20℃) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Physical and Chemical Properties | Chemical quality is a white solid, m.p.235 ℃ (decomposition), soluble in water, insoluble in organic solvents, easy to absorb moisture. |
| Use | Uses S-methyl isothiourea sulfate is an intermediate for the preparation of guanidine, which can be used to prepare fungicides diimuron, ethvery, insecticides pyrimidophanate, anti-aphidb, etc. Used as intermediate of medicine and pesticide |
S-EIT hemihydrate - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | UM9200000 |
| TSCA | Yes |
| HS Code | 29309070 |
S-EIT hemihydrate - Upstream Downstream Industry
S-EIT hemihydrate - Uses and synthesis methods
biological activity
(S)-Methylisothiourea sulfate are inhibitors of iNOS.
Target
Target Value
iNOS
Production method
the preparation method is to add a little water into the reactor, partially dissolve thiourea under stirring, stir for 10min under cooling in a cold water bath, then add resteamed dimethyl sulfate, quickly install two spherical condenser tubes to prevent sudden boiling, remove the cold water bath, spontaneously release heat after the reaction, suddenly boil after 5min, at this time the solid has been mostly dissolved, after the reflux is weakened and balanced, heat is heated and refluxed for 1h, let stand overnight, the reactants solidify, add 95% ethanol and stir for a while, cool with ice water for 0.5h, filter, and wash with 25% ethanol to obtain the finished product.
Last Update：2024-04-10 22:29:15
S-EIT hemihydrate - Nature
| Solubility | H2O: 0.1 g/mL, clear, colorless |
| Sensitivity | Hygroscopic |
| BRN | 3917217 |
| EPA chemical information | Carbamimidothioic acid, methyl ester, sulfate (2:1) (867-44-7) |
Last Update：2024-04-09 19:04:56
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View History
S-EIT hemihydrate
2-(Phenanthridin-6-yl)benzoic acid methyl ester
3-hydroxypiperidin-2-one
1-chloro-6-nitro-4-{3-nitrophenyl}-2-({2-nitrophenyl}sulfanyl)-2,3,3a,4,5,9b-hexahydro-1H-cyclopenta[c]quinoline
噻唑,2-甲基-4-(4-硝基苯基)-
1H-indole-2-carbothioamide
[Ethyl cyano(hydroxyimino)acetato-O2]tri-1-pyrrolidinylphosphonium hexafluorophosphate
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-n-1-piperidinyl-1h-pyrazole-3-carboxamide monohydrochloride
tert-Butyl (4-(2-(2-hydroxyethoxy)ethoxy)butyl)carbamate
1-[3-(trifluoromethyl)phenyl]propan-2-one
2-(Phenanthridin-6-yl)benzoic acid methyl ester
3-hydroxypiperidin-2-one
1-chloro-6-nitro-4-{3-nitrophenyl}-2-({2-nitrophenyl}sulfanyl)-2,3,3a,4,5,9b-hexahydro-1H-cyclopenta[c]quinoline
噻唑,2-甲基-4-(4-硝基苯基)-
1H-indole-2-carbothioamide
[Ethyl cyano(hydroxyimino)acetato-O2]tri-1-pyrrolidinylphosphonium hexafluorophosphate
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-n-1-piperidinyl-1h-pyrazole-3-carboxamide monohydrochloride
tert-Butyl (4-(2-(2-hydroxyethoxy)ethoxy)butyl)carbamate
1-[3-(trifluoromethyl)phenyl]propan-2-one
Downstream Products for S-EIT hemihydrate
4-Chloro-2-(methylthio)pyrimidine-5-carbonitrile
1-Methyl-3-nitro-1-nitrosoguanidine
ETHYL 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE
Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate
IMINOCTADINE TRIACETATE
1,1-DIMETHYLGUANIDINE SULFATE
5-[2-(METHYLTHIO)PYRIMIDIN-4-YL]THIOPHENE-2-SULFONYL CHLORIDE
5-Chloro-2-(methylsulfonyl)pyrimidine
1-Methyl-3-nitro-1-nitrosoguanidine
ETHYL 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE
Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate
IMINOCTADINE TRIACETATE
1,1-DIMETHYLGUANIDINE SULFATE
5-[2-(METHYLTHIO)PYRIMIDIN-4-YL]THIOPHENE-2-SULFONYL CHLORIDE
5-Chloro-2-(methylsulfonyl)pyrimidine