SAG (cyclopamine antagonist)
SAG
CAS: 912545-86-9
Molecular Formula: C28H28ClN3OS
SAG (cyclopamine antagonist) - Names and Identifiers
SAG (cyclopamine antagonist) - Physico-chemical Properties
| Molecular Formula | C28H28ClN3OS |
| Molar Mass | 490.06 |
| Density | 1.30±0.1 g/cm3(Predicted) |
| Boling Point | 688.6±55.0 °C(Predicted) |
| Solubility | Soluble in DMSO (up to 20 mg/ml), in DMF (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml). |
| Appearance | lyophilized solid |
| Color | white to beige |
| pKa | 10?+-.0.40(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| Stability | Light Sensitive |
| Sensitive | Light Sensitive |
| In vitro study | SAG (0.1 nM-100 μM; 30 h) induces firefly luciferase expression in Shh-LIGHT2 cells with an EC 50 of 3 nM and then inhibits expression at higher concentrations. SAG (1-1000 nM; 1 h) competes for the binding of BODIPY-cyclopamine to Smo-expressing Cos-1 cells, yielding an apparent dissociation constant (K d ) of 59 nM for the SAG/Smo complex. SAG (100 nM) inhibits the inhibitory effect of ShhN-induced pathway activation by Robotnikinin. SAG (250 nM; 48 h) significantly increases SMO mRNA and protein expression in MDAMB231 cells. SAG (250 nM; 24 and 48 h) increases CAXII mRNA expression in MDAMB231 cells at 24h in normoxic and hypoxic conditions in MDAMB231 cells. SAG (250 nM; 24 h) increases MDAMB231 cells migration. |
| In vivo study | SAG (1.0 mM) induces more osteogenesis mainly at the defect borders and a significant increase in BV/TV at the eight week timepoint in CD-1 mice. SAG (15-20 mg/kg; i.p.) induces pre-axial polydactyly prevalently in a dose-dependent manner in mice. Animal Model: Pregnant C57BL/6J mice Dosage: 15, 17, 20 mg/kg Administration: A single i.p. Result: Effective in ca. 80% of the embryos and increased Gli1 and Gli2 mRNA expression in the limb bud, with Gli1 mRNA being the most upregulated at the dose of 20 mg/kg. |
SAG (cyclopamine antagonist) - Risk and Safety
| UN IDs | UN 2811 6.1 / PGIII |
SAG (cyclopamine antagonist) - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.041 ml | 10.203 ml | 20.406 ml |
| 5 mM | 0.408 ml | 2.041 ml | 4.081 ml |
| 10 mM | 0.204 ml | 1.02 ml | 2.041 ml |
| 5 mM | 0.041 ml | 0.204 ml | 0.408 ml |
Last Update：2024-01-02 23:10:35
SAG (cyclopamine antagonist) - Introduction
SAG is a chemical substance with the chemical name saxamate chloride. The following is a description of some of the properties, uses, methods and safety information of SAG:
Nature:
- SAG is a colorless to pale yellow solid with a pungent odor.
-It has low solubility in water and is soluble in organic solvents such as ethanol and dimethylformamide.
- SAG is stable in the air and decomposes at high temperatures.
Use:
- SAG is an important organic synthesis intermediate, which has a wide range of applications in pharmaceutical synthesis and organic synthesis.
-It can be used as a reagent to synthesize a variety of biologically active compounds.
- SAG can also be used for the preparation of catalysts and the manufacture of optoelectronic devices.
Preparation Method:
- SAG is prepared in a variety of ways, the commonly used method is through the reaction of chlorinated acid and alcohol dehydration.
-In addition, saxamic acid and thionyl chloride can also be used to react to obtain SAG.
Safety Information:
- SAG has a stimulating effect on the skin and eyes, and should be washed in time after contact.
-Wear appropriate protective equipment such as gloves and glasses during operation.
-Avoid fire and high temperature when storing and using SAG.
- SAG is a chemical and should be kept away from children and pets.
Please note that when using SAG or any chemical substances, it is important to carefully read and follow the relevant safety data sheets and operating instructions to ensure safe operation and risk control. In addition, if necessary, please consult professional chemists for advice and guidance.
Nature:
- SAG is a colorless to pale yellow solid with a pungent odor.
-It has low solubility in water and is soluble in organic solvents such as ethanol and dimethylformamide.
- SAG is stable in the air and decomposes at high temperatures.
Use:
- SAG is an important organic synthesis intermediate, which has a wide range of applications in pharmaceutical synthesis and organic synthesis.
-It can be used as a reagent to synthesize a variety of biologically active compounds.
- SAG can also be used for the preparation of catalysts and the manufacture of optoelectronic devices.
Preparation Method:
- SAG is prepared in a variety of ways, the commonly used method is through the reaction of chlorinated acid and alcohol dehydration.
-In addition, saxamic acid and thionyl chloride can also be used to react to obtain SAG.
Safety Information:
- SAG has a stimulating effect on the skin and eyes, and should be washed in time after contact.
-Wear appropriate protective equipment such as gloves and glasses during operation.
-Avoid fire and high temperature when storing and using SAG.
- SAG is a chemical and should be kept away from children and pets.
Please note that when using SAG or any chemical substances, it is important to carefully read and follow the relevant safety data sheets and operating instructions to ensure safe operation and risk control. In addition, if necessary, please consult professional chemists for advice and guidance.
Last Update：2024-04-09 15:16:35
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Spot supply
Product Name: SAG Visit Supplier Webpage Request for quotationCAS: 912545-86-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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