Name | 5,6,7,8-Tetrahydro-2-naphthol |
Synonyms | 6-Tetralinol TETRAHYDRO-2-NAPHTHOL SALOR-INT L497681-1EA tetrahydro-beta-naphthol 5,6,7,8-tetrahydro-2-naphtho 5,6,7,8-Tetrahydro-2-naphtol 5,6,7,8-Tetrahydro-2-naphthol 2-Naphthol, 5,6,7,8-tetrahydro- 5,6,7,8-Tetrahydro-beta-naphthol 6-Hydroxy-1,2,3,4-tetrahydronaphthalene 5,6,7,8-Tetrahydro-2-hydroxynaphthalene |
CAS | 1125-78-6 |
EINECS | 214-410-4 |
InChI | InChI=1/C10H12O/c11-10-6-5-8-3-1-2-4-9(8)7-10/h5-7,11H,1-4H2 |
InChIKey | UMKXSOXZAXIOPJ-UHFFFAOYSA-N |
Molecular Formula | C10H12O |
Molar Mass | 148.2 |
Density | 1.0552 |
Melting Point | 59-61 °C (lit.) |
Boling Point | 275-276 °C (lit.) |
Flash Point | >230°F |
Water Solubility | 1.5g/L(20 ºC) |
Solubility | 1.5g/l |
Appearance | White to orange to brown powder or crystal |
Color | Beige |
BRN | 1101302 |
pKa | 10.48(at 25℃) |
Storage Condition | Inert atmosphere,Room Temperature |
Refractive Index | 1.5000 (estimate) |
MDL | MFCD00001738 |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection |
WGK Germany | 3 |
RTECS | QL5300000 |
HS Code | 29071900 |
NIST chemical information | Information provided by: webbook.nist.gov (external link) |
use | 5,6,7, 8-tetrahydro-2-naphthol can be used to prepare molecularly imprinted polymers and Mer inhibitors. Organic and pharmaceutical synthetic intermediates can be used to synthesize antifungal drug liranate. |
Application Example | 5,6,7, 8-tetrahydro-2-naphthol can be used to prepare Mer inhibitors with the following structure. Ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a potential cause of tumor cell survival gene products and chemotherapy resistance in acute lymphoblastic leukemia (ALL) cells. Acute lymphoblastic leukemia (ALL) is the most common malignant tumor in children. The common type can be cured by chemotherapy in 75%-85% cases. |