SB 220453

Name	Tonabersat
Synonyms	SB220453 SB 22045 SB 220453 Tonabersat TONABERSAT Tonabersat [ban, inn] N-((3S,4S)-6-Acetyl-3-hydroxy-2,2-diMethylchroMan-4-yl)-3-chloro-4-fluorobenzaMide 2H-Benzo(B)pyran-3-ol, 6-acetyl-4-(3-chloro-4-fluorobenzoylamino)-3,4-dihydro-2,2-dimethyl- N-[(3S,4S)-6-Acetyl-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-3-chloro-4-fluoro-benzamide
CAS	175013-84-0

Molecular Formula	C20H19ClFNO4
Molar Mass	391.82
Density	1.38
Boling Point	554.5±50.0 °C(Predicted)
Appearance	powder
Color	white to beige
pKa	11.86±0.60(Predicted)
Storage Condition	2-8°C
In vitro study	Tonabersat, a novel benzopyran derivative, inhibits cortical spreading depression (CSD) and therefore might be able to inhibit the early migraine mechanisms.
In vivo study	Treatment with Tonabersat (10 mg/kg) significantly inhibits progression of metastatic lesions. Addition of NSC 241240 to either agent profoundly inhibits brain metastasis.

UN IDs

UN 3077 9 / PGIII

Last Update：2024-01-02 23:10:35

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CAS: 175013-84-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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SB 220453

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