SL0101 1

Name	SL0101
Synonyms	SL0101 SL-0101 SL 0101 SL0101-1 SL0101 1 SL-0101-1 RSK Inhibitor, SL0101 Kaempferol 3-O-(3'',4''-di-O-acetyl-alpha-L-rhamnopyranoside) 3-(3-O,4-O-Diacetyl-α-L-rhamnopyranosyloxy)-4',5,7-trihydroxyflavone 2-(4-Hydroxyphenyl)-4-oxo-5,7-dihydroxy-4H-1-benzopyran-3-yl 3-O,4-O-diacetyl-α-L-rhamnopyranoside 2-(4-Hydroxyphenyl)-3-(3-O,4-O-diacetyl-α-L-rhamnopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one 3-[(3,4-Di-O-acetyl-6-deoxy-α-L-Mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
CAS	77307-50-7

Molecular Formula	C25H24O12
Molar Mass	516.45
Density	1.57±0.1 g/cm3(Predicted)
Melting Point	128-132°C
Boling Point	753.0±60.0 °C(Predicted)
Solubility	Acetone (Slightly), Methanol (Slightly)
Appearance	Yellow solid
Color	Pale Yellow to Brown
pKa	6.20±0.40(Predicted)
Storage Condition	Store at -20°C
In vitro study	SL 0101-1 (SL0101) shows proliferation inhibition in human breast cancer cell line MCF-7 and produces a cell cycle block in G 1 phase.

biological activity	SL 0101-1 (SL0101) is a naphthol glycoside extracted from tropical plant F. refracta. It is a cell-penetrating, selective, reversible, ATP-competitive p90 ribosomal S6 kinase (RSK) inhibitor with an IC50 value of 89 nM. SL 0101-1 (SL0101) is a selective RSK1/2 inhibitor with a Ki value of 1 μM.
target	IC50: 89 nM (RSK). Ki: 1 μM (RSK1/2).
in vitro study	SL 0101-1 (SL0101) shows proliferation inhibition in human breast cancer cell line MCF-7 and produces a cell cycle block in G 1 phase.

Last Update：2024-04-09 19:05:04

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CAS: 77307-50-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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