SODIUM ESTRONE-2,4,16,16-D4 SULFATE - Names and Identifiers
Synonyms | [2H4]-Sodium Estrone Sulfate ESTRONE-2,4,16,16-D4 3-SULFATE SODIUM ESTRONE-2,4,16,16-D4 SULFATE (Estrone-2,4,16,16-D4-Sodium Sulfate) ESTRONE-2,4,16,16-D4 3-SULFATE, SODIUM S Estrone-2,4,16,16-d4 3-sulfate sodium salt estrone-2,4,16,16-D4 3-sulfate, sodium salt
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CAS | 285979-80-8
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SODIUM ESTRONE-2,4,16,16-D4 SULFATE - Physico-chemical Properties
Molecular Formula | C18H23NaO5S
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Molar Mass | 374.43 |
Melting Point | 300°C(lit.) |
Storage Condition | -20°C |
SODIUM ESTRONE-2,4,16,16-D4 SULFATE - Risk and Safety
Hazard Symbols | T - Toxic
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Risk Codes | R45 - May cause cancer
R60 - May impair fertility
R61 - May cause harm to the unborn child
R36/37/38 - Irritating to eyes, respiratory system and skin.
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Safety Description | S53 - Avoid exposure - obtain special instructions before use.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
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WGK Germany | 3 |
SODIUM ESTRONE-2,4,16,16-D4 SULFATE - Introduction
(also known as estradiol-2, 4,16,16-d4 3-sulfate sodium salt) is an important isotopically labeled compound that contains the deuterium (D) isotope in its structure. The following is a description of its nature, use, preparation and safety information:
Nature:
-Chemical formula: C20H20D4NaO9S
-Molecular weight: 484.46g/mol
-Appearance: White crystalline powder
-melting point: 160-164 ℃
-Solubility: Soluble in water, solubility is larger.
Use:
-Labeled compound: Because it contains heavy deuterium isotopes, it can be used as a labeled compound in research analysis. In the study of drug metabolism, isotope labeling is often used to track and study the absorption, distribution, metabolism and excretion of drugs. It can be used to label estradiol metabolites for analysis of drug metabolic pathways.
Method:
-can be prepared by chemical synthesis. A common method of preparation is to start with the estrol 2,4,16,16-d4 starting material, react with sulfuric acid under appropriate conditions to give the estrone 2,4,16,16-d4, and then react with sodium hydroxide to give the corresponding 3-sodium salt.
Safety Information:
-It is generally less toxic under normal use and handling.
-Follow laboratory safety practices and wear appropriate personal protective equipment, such as lab gloves and goggles.
-Compliance with relevant chemical waste handling regulations is required during handling and disposal.
Last Update:2024-04-09 21:04:16