Name | Sodium Orthovanadate(V) |
Synonyms | SODIUM VANADATE trisodiumvanadate SODIUM VANADATE, ORTHO trisodiumorthovanadate Sodium Orthovanadate(V) Vanadicacidtrisodiumsalt vanadic(ii)acid,trisodiumsalt trisodium trioxido(oxo)vanadium (beta-4)-vanadate(vo43-trisodium |
CAS | 13721-39-6 |
EINECS | 237-287-9 |
InChI | InChI=1/3Na.4O.V/q3*+1;;;;;-3/r3Na.O4V/c;;;1-5(2,3)4/q3*+1;-3 |
Molecular Formula | Na3VO4 |
Molar Mass | 183.91 |
Melting Point | 850-866°C(lit.) |
Water Solubility | soluble |
Solubility | Soluble in water (50 mg/ml, clear to hazy, colorless to faint yellow solution). |
Appearance | White to white-like powder |
Color | off-white |
Exposure Limit | NIOSH: Ceiling 0.05 mg/m3 |
Storage Condition | Sealed in dry,Room Temperature |
Stability | Stable. Incompatible with strong oxidizing agents. |
Sensitive | Easily absorbing moisture |
MDL | MFCD00003511 |
Use | The study of diabetes in medicine. Ink. Dye fur. Photograph. Plant inoculation. |
In vitro study | In the presence of oxidizing agents vanadium ions exist as the hydrated monomer of Sodium orthovanadate (vanadate: HVO4 2- or H2VO 4- ) at micromolar concentations near neutral pH. Sodium orthovanadate (vanadate) also begins to polymerize at concentrations greater than 0.1 mM at neutral pH. The yellow-orange solutions of decavanadate can be converted to the colorless solutions of monomeric Sodium orthovanadate (vanadate) by dilution after a period of many hours. The process is hastened by boiling at pH 10, which encourages the kinetically sluggish depolymerization process. Sodium orthovanadate could alter the phosphorylation status of ASK1 at serine 83 and threonine 845 induced by ischemia. Sodium orthovanadate could increase the tyrosine posphorylation of PTEN and further inhibit the activation of ASK1 via activating Akt during cerebral ischemia. |
Hazard Symbols | Xn - Harmful |
Risk Codes | 20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
Safety Description | S22 - Do not breathe dust. S36 - Wear suitable protective clothing. |
UN IDs | UN3285 |
WGK Germany | 3 |
RTECS | YW1120000 |
TSCA | Yes |
HS Code | 28419030 |
Hazard Class | 6.1 |
Packing Group | III |
Reference Show more | 1. [IF=3.935] Yi Tao et al."Towards the identification of alkaline phosphatase binding ligands in Li-Dan-Hua-Shi pills: A Box-Behnken design optimized affinity selection approach tandem with UHPLC-Q-TOF/MS analysis."J Pharmaceut Biomed. 2018 May;154:486 2. [IF=4.142] Qu Fei et al."Ratiometric detection of alkaline phosphatase based on aggregation-induced emission enhancement."Anal Bioanal Chem. 2019 Nov;411(28):7431-7440 3. [IF=8.128] Jing Xu et al."Interlayer-expanded VS2 nanosheet: Fast ion transport, dynamic mechanism and application in Zn2+ and Mg2+/Li+ hybrid batteries systems."J Colloid Interf Sci. 2022 Aug;620:119 |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
application | sodium vanadate is an inorganic salt compound, mainly used as catalyst, paint drier, mordant, corrosion inhibitor, etc., and also used to prepare other vanadium salts. |
Biological activity | Sodium orthovanadate are inhibitors of protein tyrosine phosphatase, alkaline phosphatase and some ATPases, and most likely act as phosphate analogs. |
target | PPTPase. |
use | inhibitors of several phosphatases and phosphokinase |