Name | SPECTINOMYCIN SULFATE |
Synonyms | U-18409E Einecs 245-578-7 U 18409E, ANTIBIOTIC SPECTINOMYCIN SULFATE SPECTINOMYCIN SULPHATE Actinospectacin sulfate |
CAS | 23312-56-3 |
EINECS | 245-578-7 |
Molecular Formula | C14H26N2O11S |
Molar Mass | 430.43 |
Boling Point | 583℃ |
Flash Point | >110°(230°F) |
Water Solubility | Soluble in DMSO or water |
Storage Condition | Store at?0-5°C |
WGK Germany | 3 |
Qin, Korean and British , Yanfen Wang , Yan qianyin , he Qinglan , Gao Lan , he Yulan
Abstract:
Objective to establish a method for the determination of residual organic solvents in spectinomycin sulfate. Methods headspace sampling capillary gas chromatography was used, the column was Elite-5 capillary column, the carrier gas was nitrogen, FID detector, n-propanol was the internal standard substance, pure water was the dissolution medium, the residual amount of acetone in spectinomycin sulfate was determined. Results acetone and N-propanol were completely separated, and there was a good linearity within the investigated concentration range (r = 0.9998). The limit of quantification of acetone was 6.88 × 106g · mL-1. The RSD of precision was 1.5%,0.8% and 0.5%, respectively, less than 5%. The average recovery was 97.15% ~ 100.63%, ranging from 97% to 103%. Conclusion The method is simple, sensitive, accurate and reliable. It is suitable for the determination of residual organic solvents in spectinomycin sulfate.Key words:
Internal Standard method spectinomycin sulfate
DOI:
10.3969/j.issn.1672-7738.2009.08.012
year:
2009
Abstract:
Key words:
successful development spectinomycin sulfate Shandong Lukang Pharmaceutical Group industrial production pilot
year:
2002