Saccharine Sodium
Sodium saccharine
CAS: 128-44-9
Molecular Formula: C7H5NNaO3S
Saccharine Sodium - Names and Identifiers
| Name | Sodium saccharine |
| Synonyms | madhurin 204-886-1 kristallose Sodium Saccharin Sodium saccharine Saccharine Sodium Sodium Saccharin Soluble o-Benzoic acid sulfimide sodium o-sulfonbenzoicacidimidesodiumsalt 1,2-benzisothiazol-3-olate 1,1-dioxide sodium 1,2-benzothiazol-3-olate 1,1-dioxide Sodium 1,1-dioxo-1,2-benzothiazol-2-id-3-one 2-Sodio-1,2-benzisothiazol-3(2H)-one 1,1-dioxide 1,2-Benzothiazol-3(2H)-one 1,1-dioxide sodium salt 1,2-benzisothiazol-3(2H)-one 1,1-dioxide, sodium salt |
| CAS | 128-44-9 |
| EINECS | 204-886-1 |
| InChI | InChI=1/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9)/p-1 |
| InChIKey | WINXNKPZLFISPD-UHFFFAOYSA-M |
Saccharine Sodium - Physico-chemical Properties
| Molecular Formula | C7H5NNaO3S |
| Molar Mass | 206.17 |
| Density | 1.69[at 20℃] |
| Melting Point | >300°C |
| Boling Point | 438.9°C at 760 mmHg |
| Flash Point | 219.3°C |
| Water Solubility | >=10 g/100 mL at 20 ºC |
| Solubility | Soluble in water and ethanol. |
| Vapor Presure | 0Pa at 25℃ |
| Appearance | White crystalline powder (colorless to white orthorhombic crystal plate crystal or white crystalline weathered powder) |
| Color | White crystals or a white, crystalline efflorescent powder |
| Odor | odourless or with a faint, aromatic odour |
| pKa | 0.003-0.003[at 20 ℃] |
| Storage Condition | 0-6°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Physical and Chemical Properties | Colorless monoclinic crystals. The melting point of 229 deg C (decomposition), the relative density of 0.828. Sublimated under vacuum into needle-like crystals. Soluble in ethanol, acetone, chloroform-soluble and ether. |
| Use | Used as food flavoring agent and diagnostic drug |
Saccharine Sodium - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 2 |
| RTECS | DE4550000 |
| Toxicity | LD50 oral in rat: 14200mg/kg |
Saccharine Sodium - Upstream Downstream Industry
Saccharine Sodium - Reference
| Reference Show more | 1. Shen Yanfei, Zhu Xianna, Yao Cheng, et al. Valve switching ion chromatography simultaneously detects sugars, sweeteners and preservatives in beverages [J]. Food Science, 2018(1):311-316. 2. Bingxue Hu, Da-Wen Sun, Hongbin Pu, Qingyi Wei, A dynamically optical and highly stable pNIPAM @ Au NRs nanohybrid substrate for sensitive SERS detection of malachite green in fish fillet, Talanta, volume 218, 2020, 12118 8, ISSN 0039-9140, https://doi.org/ 3. Yin, Kai-Jing, et al. "Effects of different sweeteners on behavior and neurotransmitters release in mice." Journal of food science and technology 57.1 (2020): 113-121.https:// doi.org/10.1007/s13197-019-04036-6 4. [IF = 6.057] Bingxue Hu et al. "A dynamically optical and highly stable pNIPAM @ Au NRs nanohybrid substrate for sensitive SERS detection of malachite green in fish fillet." Talanta. 2020 Oct;218:121188 |
Saccharine Sodium - Reference Information
| FEMA | 2997 | SACCHARINE, SODIUM SALT |
| LogP | -2.84-0.11 at 25℃ |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| identification test | in which: 1, 2 and 3 are the same as those in "saccharin ammonium (02302)" identification test method 1, 2 and 3. Easily soluble in water (1g/1.5 m1), slightly soluble in ethanol (1g/50 m1). Measured according to OT-42 method. The burning residue of 2g sample was positive for sodium salt test (IT-28). |
| content analysis | accurately weigh 0.3g of pre-dried sample and dissolve in 20ml glacial acetic acid. Add 2 drops of crystal violet test solution (TS-74) as indicator, titrate with 0.1mol/L perchloric acid, and take the titration end point when the color of the solution changes from purple to blue. At the same time, a blank control test is carried out to eliminate unnecessary errors as much as possible. Perchloric acid is equivalent to saccharin (C7H4NNaO3S)20.52mg per mI0.1mol/L. |
| toxicity | LD50 oral in rat: 14200mg/kg |
| usage limit | GB 2760-2002(g/kg): beverages, pickles, compound seasonings, candied fruits, prepared wine, ice cream, ice cream, popsicles, cakes, biscuits, bread, 0.15; Melon seeds, 1.2; Dried fruits, nuts, spiced beans, fried beans, 1.0; plum, apricot, licorice olive, licorice kumquat, dried mango, dried fig, plum, tangerine peel, dried bayberry, 5.0. FEMA(mg/kg): soft drink 72; Cold drink 150; Candy 2100~2600; Baked food 12. FDA,§ 180.37(2000): Beverages, fruit juices, solid beverages, 12mg/28.41m1 liquid, sweetness equivalent to a tablespoon of 20mg; 30mg per serving of processed food of specified size. USDA,9CFR,§ 318.7(2000): Pork (Bacon) 0.01%. |
| use | non-nutritious sweetener. used as food sweetener and diagnostic medication |
| Production method | Chlorosulfonation of toluene and chlorosulfonic acid is performed to obtain oily o-toluenesulfonyl chloride and by-product crystalline p-toluenesulfonyl chloride. After separation, it reacts with ammonia and oxidizes to obtain saccharin, which is then alkalized by sodium hydroxide. I see "02331". |
Last Update：2024-04-09 21:04:16
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Raw Materials for Saccharine Sodium
Downstream Products for Saccharine Sodium