Selinexor (KPT-330)

Name	Selinexor (KPT-330)
Synonyms	KPT-330 Aloradine Selinexor KPT330,Selinexor KPT-330,Selinexor Selinexor (KPT-330) (Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyrazin-2-yl)acrylohydrazide (2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyrazinyl)hydrazide 2-Propenoic acid, 3-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-, 2-(2-pyrazinyl)hydrazide, (2Z)-
CAS	1393477-72-9

Molecular Formula	C17H11F6N7O
Molar Mass	443.31
Density	1.55±0.1 g/cm3(Predicted)
Solubility	Soluble in DMSO (up to at least 25 mg/ml). or in Ethanol (up to at least 25 mg/ml)
Appearance	solid
Color	Off-white
pKa	9.74±0.43(Predicted)
Storage Condition	-20°C
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Physical and Chemical Properties	Bioactive Selinexor (KPT-330, ATG-010) is an orally bioavailable selective CRM1 inhibitor. Phase 2.
Target	Target Value CRM1 (Cell-free assay)
In vitro study	KPT-330, as a clinical candidate for KPT-185, has a similar effect on the survival of T-ALL cells and rapidly triggers an apoptotic response. KPT-330 also reduced MOLT-4,Jurkat,HBP-ALL,KOPTK-1,SKW-3, and DND-41 cell line growth with an IC50 of 34-203 nM.
In vivo study	In vivo, KPT-330 significantly inhibited the growth of T-ALL cells (MOLT-4) and AML cells (MV4-11), with little toxicity to normal hematopoietic cells. KPT-330 treatment of SCID mice with diffuse human multiple myeloma (MM) bone lesions inhibits MM-induced osteolysis and prolongs life. In addition, KPT-330 directly impaired osteoclast formation and bone resorption by inhibiting RANKL-induced NF-κB and NFATc1, with minimal effects on osteoblasts and BMSCs.

Raw Materials	3,5-Bis(trifluoromethyl)benzonitrile 2-Hydrazinopyrazine 3,5-DI(TRIFLUOROMETHYL)BENZENE-1-CARBOTHIOAMIDE (Z)-3-(3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid 3,5-Di(trifluoromethyl)benzamide (Z)-isopropyl 3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate
Downstream Products	3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazole

Last Update：2024-01-02 23:10:35

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Product Name: Selinexor (KPT-330) Visit Supplier Webpage Request for quotation
CAS: 1393477-72-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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Selinexor (KPT-330)

Raw Materials for Selinexor (KPT-330)

Downstream Products for Selinexor (KPT-330)

3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazole

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