Semen Hoveniae extract
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Semen Hoveniae extract - Names and Identifiers
| Synonyms | Semen Hoveniae Zhijuzi Extract Semen Hoveniae P.E. Semen Hoveniae extract Japanese Raisin Tree Seed |
Semen Hoveniae extract - Physico-chemical Properties
| Storage Condition | Room Temprature |
Semen Hoveniae extract - Reference Information
| plant extract | Hovenia dulcis thob. The dried mature seeds were extracted as raw materials, containing flavonoids active ingredients such as kaempferol, folium, myricetin, quercetin, hydrogen myricetin and anthraquinone compounds such as emodin. With anti-lipid peroxidation, protection of liver injury, anti-alcohol, anti-liver fibrosis and anti-aging and anti-fatigue effects. |
| extracted from | Hovenia Hovenia Hovenia Lindl.. N. Hovenia Hovenia H.dulcis Thunb. Hovenia plants, 3 species and 2 varieties all over the world; Both produced in China, 2 of which are for medicinal use. [Base source] Dried mature seeds of Hovenia dulcis Thunb. [Alias] Golden Pear, jujube, chicken claw tree, chicken paw, sweet night, Wanzi fruit, Marigold fruit, golden fruit tree, Dragon Claw, orange jujube, chicken orange, Wood coral, etc. [Habitat distribution] in the mountain forest edge or sparse forest or open land below an altitude of 2100m, usually there is cultivation in the garden. Distributed in Gansu, Shaanxi, Henan, Jiangsu, Anhui, Zhejiang, Jiangxi, Fujian, Hubei, Hunan, Guangdong, Guangxi, Sichuan, Guizhou, Yunnan, Tibet. It is also found in India, Nepal, sikkin, Bhutan and northern Myanmar. Plant morphology: deciduous trees, up to 25m in size, with brown or purplish-black branchlets, covered with pubescence or hairless, with white perforations. Leaf blade thick papery or papery, broadly ovoid, oval-ovoid, 8-17cm in length, 6-12cm in width, Apex long-acuminate or acuminate, base truncated or cordate, margin with regular serrulate, surface hairless, abaxial surface along the veins or vein axillae often covered with pubescence or hairless, petiole 2-5cm long. Symmetrically dipterygoid panicles, terminal or axillary, with brown pubescence; Flowers 5-fold, amphiphilic, small, 5-6.5 in diameter, sepals triangular, with reticulate veins or longitudinal stripes, 1.9-2.2 in length, petals and sepals alternation, white or white-green, oval-spatula-shaped, with short claw, with stamens held by petals, filaments acicular-linear, base free from claw, anthers dorsifixed, disk succulent, pilose; Ovary superior, mostly hidden within disk. Baccaceous stone subglobose, with a residual style at the apex, with a persistent calyx tube at the base, 5-6.5 in diameter, hairless, yellow-brown at maturity, with expanded, twisted, meat quality; Seeds 3, oblate-spherical, tan or black-purple, shiny, 3.2-4.5 in diameter. Flowering 5~7 months, the fruit period 8~10 months. Fig.1 Hovenia dulcis Thunb |
| Chemical composition | mainly contains alkaloids, flavonoids, saponins, organic acids, glucose and other components. 1. Alkaloids components from Hovenia dulcis Thunb., the β-Carbo ne alkaloid compound ryegrass alkaloid was obtained. 2. Flavonoids have been isolated from Hovenia dulcis Thunb. A variety of flavonoids, such as quercetin, dihydrokaempferol, (+)-3, 3 ' , 5, 5', 7-pentahydroxy dihydroflavone, (+)-Dihydromyricetin, emodin, kaempferol, 3-methoxy-4-hydroxy-benzoic acid, apigenin, myricetin, 4', 5', 7-trihydroxy-3 ', 5'-dimethoxyflavone, etc. 3. Fatty acid composition of Hovenia dulcis Thunb fatty acid oil has been divided into 27 kinds of fatty acids, including 5 kinds of unsaturated fatty acids, 22 kinds of saturated fatty acids, the higher content of Delta 9 octaenoic acid methyl ester (26.24%), decanoate methyl ester (14.72%), methyl decanoate (7.99%), methyl 9-oxononanoate (7.20%), methyl octanoate (4.79%), and methyl eicosanoate (1.79%). 4. Saponin and glycoside components at present, have been isolated from hovenin C, D, g, G', H(hov eno side C, D, g, G', H), the corresponding aglycones of D and G are Zizyphus jujube aglycones; The contents of A1, A2, B1, B2(ho venidulciosideA1, A2, B1, B2), I .e., 3-O- [Β-l-r hamnpy ranosy-(1 → 2)-β-dgluco py rano sy I] ho venidulcigena, 3-O-[ β-D-g l-uco py rano syI] ho venidulcigena, 3-O-[ β-L-rhamno py ranosy I-(1 → 2)-β-Dgluco py rano sy Ⅰ] ho venidulc-igenin B, 3-O-[ β-dg l-ico py rano syI] ho venidulcigenb; north of the jujube glycosides III (hodulo side III). 5. Other components are additionally isolated to give other components, such as 3 β-dihydroxybetulinic acid, betulin, 3 β-hydroxy-18 (19) terpenoids such as-ene-oleane-28-carboxylic acid, carrot glycosides, β-sitosterol (β-sitosettero l). Glucose, potassium nitrate, potassium malate;(+) catechin [(+)g allocatechin], etc. |
| pharmacological action | 1. Anti-Fatigue study showed that Hovenia dulcis Thunb ethanol extract had good anti-fatigue effect, increased glycogen storage and reduced the accumulation of urea nitrogen after exercise. 2. Anti-aging effect studies show that different doses of Hovenia dulcis Thunb extract can improve the learning and memory ability of D-galactose-induced subacute aging mice, this effect may be partly caused by increasing the activity of antioxidant enzymes in the body, reducing the formation of lipid peroxide and improving the antioxidant capacity of the body. 3. The study of the effect on the liver showed that the water extract of Hovenia dulcis Thunb had obvious therapeutic effect on NASH induced by high fat diet in rats, and the effect was better than that of Tiopronin combined with Tiopronin treatment group. The mechanism of action may be related to the improvement of insulin sensitivity, anti-oxidation, inhibition of inflammatory cytokines and so on. 4. Protective effect of ethyl acetate solution of Hovenia dulcis Thunb methanol extract, in which catechin and Catechol can effectively clean up DPPH and ABTS free radicals, and show anti-glutamate induced neurotoxicity in rat hippocampal HT22 cells, has the function of protecting nerve. 5. The effect of intravenous injection of 3.4~6.7mg/kg and water extract of Hovenia dulcis Thunb on circulatory system can cause the mean arterial pressure of normal anesthetized cats to decrease by 13~27mmHg; intravenous injection of 0.2~0.4mg/kg aqueous solution of n-butanol extract of Hovenia dulcis Thunb caused a decrease in mean arterial pressure of 22~24 mmHg in normal anesthetized cats. Intravenous injection of 0.2~0.4mg/kg aqueous solution of ethyl acetate extract of Hovenia dulcis Thunb had no effect on mean arterial pressure in normal anesthetized cats. Enhance the role of comprehensive physical ability of Hovenia dulcis Thunb water extract can significantly improve the cold-resistant, heat-resistant function of mice and prolong the time of swimming and climbing. Conclusion The water extract of Hovenia dulcis Thunb can enhance the comprehensive physical ability of mice. 7. Anti-alcoholism effect the extract of Hovenia dulcis Thunb can antagonize the decrease of ADH, SOD and GST activities in liver caused by long-term intake of ethanol, leading to the decrease of MDA content, which has the effect of anti-alcoholism and liver protection. |
| extraction separation | 20.0kg of dried and mature Hovenia dulcis Thunb. Was pulverized to a coarse powder and extracted by percolation with 70% ethanol. The extract was concentrated under reduced pressure to no alcoholic taste to give a total extract of 1. 8kg. The extract was suspended with appropriate amount of water, and extracted with petroleum ether, ethyl acetate and n-butanol successively. After the solvent was recovered, petroleum ether extract (108g), ethyl acetate extract (450g) and n-butanol extract (120g) were obtained. N-butanol extract (100g) with silica gel column chromatography with chloroform-methanol system gradient elution, by TLC combined to obtain five fractions, fraction 3 and fraction 4 were treated by ODS, sephadexLH-20 column and preparative HPLC gave compounds 1 (66mg), 2(7.5mg), 3(67mg), 4(28mg), 5(15mg), 6(23mg). And 7(20mg). They are: 3 ',5'-di-C-β-D-glucose-phloretin (1), isovitexin 2-o-β-d-glucoside (2), vitexin 2-o-β-d-glucoside (3), isoprinin (4), myricetin 3-o-β-d-glucoside (5) ,L-tryptophan (6) and gallic acid (7) |
| identification | Character Identification: The seed was oblate, slightly protruded on the back, with flat ventral surface, 0.3-0.5 in diameter, about 0.2 in thickness. The surface is red-brown to brown-black, smooth and glossy. Apical microbulge, with small depression at base, with a little-shaped light-colored umbilicus, with 1 longitudinal rib on ventral surface. The seed coat is hard, and the seed kernel is light yellow and oily. The taste was slightly bitter. With large grains, full, red-brown color is better. Microscopically, the outer part of the seed coat on the transverse section was 1 row of grid-like cells, about 180 μm in length and 12 μm in width, with thin outer wall and very thick lateral wall, with narrow slit-like cell cavity and enlargement near the inner wall, there was a brilliant band on the lateral side. The cells of pigment layer were in sequence, nearly ovoid or polygonal, containing brown matter. The parenchyma cells of the inner sequence were small, without pigment. Ectodermal cells were decayed, and the cell wall of the endosperm was thick, containing aleurone grains. The cell wall of cotyledon is thin, containing aleurone grains. Physical and Chemical identification take sample powder 0.1g, add diethyl ether 2ml, cold soak for 20 minutes, filter, filtrate to remove diethyl ether, add chloroform 0.5ml to dissolve, point on silica gel G plate, with n-hexane-ethyl ether-glacial acetic acid (7:3:0.1) as the developing solvent, the development distance was 10cm, and the iodine vapor developed color. Identification of Hovenia dulcis Thunb by UV spectrum take 3 samples of coarse powder, 2g each, put 50ml iodine flask, add petroleum ether, chloroform, water 20ml, shake, plug, room temperature for 3H, after filtration, the filtrate was diluted to a suitable concentration, and its ultraviolet spectrum was measured on Shimadzu UV-210A spectrophotometer. Results The Lambda maxPet of Hovenia dulcis Thunb was 216, 272nm, Max CHCl3 was 242, 278nm, Max H2O was 215, 275nm. Figure 2 is the ultraviolet spectrum of Hovenia dulcis Thunb. 1. Petroleum ether extract 2. Chloroform extract 3. Water extract |
| Health Function | It is sweet, sour and flat. Into lung, stomach and large intestine. She has functions such as nourishing yin, promoting fluid production, replenishing Qi, moistening bowel and catharsis, relieving alcohol and poison. |
Last Update：2024-04-09 15:16:55
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Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Hovenia Hovenia Extract Visit Supplier Webpage Request for quotationTel: +86-(0)731-84213302
Email: sales@staherb.cn
Mobile: +86 13875855783
QQ: 484702402
WhatsApp: +86 18374838656
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