Serotonin HCL

Serotonin HCL - Names and Identifiers

Name	Serotonin hydrochloride
Synonyms	5-HT Serotonin HCL SEROTONIN HCL TIMTEC-BB SBB003418 SEROTONINEHYDROCHLORIDE Serotonin hydrochloride SERATONIN HYDROCHLORIDE 5-Hydroxytryptamine HCL Seratonin hydrochloride SEROTONIN HYDROCHLORIDE(RG) 5-Hydroxytryptamine hydrochloride 3-(2-Aminoethyl)-5-hydroxyindole hydrochloride 5-Hydroxy-3-(2-Aminoethyl)INDOLE hydrochloride Serotonin hydrochloride,3-(2-Aminoethyl)-5-hydroxyindole hydrochloride, 5-HT, 5-Hydroxytryptamine hydrochloride
CAS	153-98-0
EINECS	628-480-2
InChI	InChI=1/C10H12N2O.ClH/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10;/h1-2,5-6,12-13H,3-4,11H2;1H
InChIKey	MDIGAZPGKJFIAH-UHFFFAOYSA-N

Serotonin HCL - Physico-chemical Properties

Molecular Formula	C10H13ClN2O
Molar Mass	212.68
Melting Point	149-154°C(lit.)
Boling Point	416.1°C at 760 mmHg
Flash Point	205.4°C
Water Solubility	soluble
Solubility	Soluble in water and methanol. 17 mg/mL H2O;22 mg/mL0.1 M HCl;5.3 mg/mL ethanol.
Vapor Presure	1.63E-07mmHg at 25°C
Appearance	White to cream powder
Color	white to off-white
Merck	14,8462
BRN	3570963
Storage Condition	2-8°C
Stability	Stable, but light sensitive and hygroscopic. Incompatible with strong oxidizing agents.
Sensitive	Light Sensitive & Hygroscopic
MDL	MFCD00012686
Physical and Chemical Properties	Solubility: H2O: 17 mg/mL storage condition: 2-8℃ sensitivity: Light Sensitive & hygropic WGK Germany:3 RTECS:NM2571000
In vitro study	Serotonin stimulates acid-base transport in the midgut progastric region in vitro. This stimulating function is considered to be the maintenance of optimal conditions for the digestion and absorption of nutrients, rather than the regulation of lymphatic acid-base balance.
In vivo study	Serotonin stimulates acid-base transport in the midgut progastric region in vitro. This stimulating function is considered to be the maintenance of optimal conditions for the digestion and absorption of nutrients, rather than the regulation of lymphatic acid-base balance.

Serotonin HCL - Risk and Safety

Risk Codes	R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
UN IDs	UN2811
WGK Germany	3
RTECS	NM2571000
FLUKA BRAND F CODES	3-8-10
HS Code	29339900
Hazard Class	6.1
Packing Group	III

Serotonin HCL - Reference

Reference

1. Gao Hui, Xing Yan, Wang Yang, Song Jinzhi, Wang Xu. Determination of monoamine neurotransmitters in human urine by solid phase extraction-high performance liquid chromatography-fluorescence method [J]. China Test, 2017,43(02):60-63 81.
2. Zheng Zhuhong, Zhao Renyun, Ding Yuting, et al. Effects of Baihe Dihuang Decoction on Behavior and Monoamine Neurotransmitters in Different Brain Regions of Insomnia Model Rats.
3. Sun, L., Chen, Y., Hou, C., Sun, X., Wang, Z., Li, S., ... & Chen, X. (2018). Neuroprotective effect of total glycosides from paeonies against neurotoxicity induced by strychnos alkaloids related to recovering the levels of neurotransmitters and neuroendoc
4. Shan, Tong, et al. "Proteomics Based Mongolian Medicine Modified Sugmul-7 Mechanism of Regulating Endocrine Function in Hyperplasia of the Breast." Clinical Medicine Research 9.1 (2020): 11.doi: 10.11648/j.cmr. 20200901.13
5. Juwita, N. A., Harahap, U., & Dalimunthe, A. (2018). Relaxation effect of ethanolic extract of Picria fel-terrae (Pugon tanoh) leaves on contraction of isolated rat's ileum contracted by serotonin. J Innov Pharm Biol Sci, 5(1), 37-41.
6. [IF=4.616] Jin-Xiu Zhou et al."Monitoring of pH changes in a live rat brain with MoS2/PAN functionalized microneedles."Analyst. 2018 Sep;143(18):4469-4475
7. [IF=3.361] Linjia Sun et al."Neuroprotective effect of total glycosides from paeonies against neurotoxicity induced by strychnos alkaloids related to recovering the levels of neurotransmitters and neuroendocrine hormones in rat serum and brain."Rsc Adv. 2018 Aug;8(5
8. [IF=9.028] Feng Cui et al."Toxicological Study on Chiral Fluoxetine Exposure to Adult Zebrafish (Danio rerio): Enantioselective and Sexual Mechanism on Disruption of the Brain Serotonergic System."Environ Sci Technol. 2021;55(11):7479-7490
9. [IF=4.128] Jia Yin et al."Dose-Dependent Beneficial Effects of Tryptophan and Its Derived Metabolites on Akkermansia In Vitro: A Preliminary Prospective Study."Microorganisms. 2021 Jul;9(7):1511
10. [IF=3.412] Yuefeng Zhang et al."Study on the Effective Material Basis and Mechanism of Traditional Chinese Medicine Prescription (QJC) Against Stress Diarrhea in Mice."Front Vet Sci. 2021; 8: 724491
11. [IF=5.279] Xiang Li et al."Zebrafish Behavioral Phenomics Links Artificial Sweetener Aspartame to Behavioral Toxicity and Neurotransmitter Homeostasis."J Agr Food Chem. 2021;69(50):15393-15402

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