Molecular Formula | C12H25NaO5S |
Molar Mass | 304.38 |
Melting Point | 159 - 162°C |
Solubility | DMSO (Sparingly, Heated), Methanol (Slightly, Heated) |
Appearance | Solid |
Color | White to Off-White |
Storage Condition | -20°C Freezer, Under inert atmosphere |
Reference Show more | 1. Wu, Jiadi, et al. "Sodium New Houttuyfonate Inhibits Candida albicans Biofilm Formation by Inhibiting the Ras1-cAMP-Efg1 Pathway Revealed by RNA-seq." Frontiers in microbiology 11 (2020): 2075.https://doi.org/10.3389/fmicb.2020.02075 2. [IF=2.1] Pei Liu et al."Sodium houttuyfonate inhibits LPS‑induced mastitis in mice via the NF‑κB signalling pathway."Mol Med Rep. 2019 Mar;19(3):2279-2286 3. [IF=7.068] Jiang Rilei et al."Sodium new houttuyfonate suppresses metastasis in NSCLC cells through the Linc00668/miR-147a/slug axis."J Exp Clin Canc Res. 2019 Dec;38(1):1-16 4. [IF=5.81] De-Wei Zhu et al."Evaluating the Therapeutic Mechanisms of Selected Active Compounds in Houttuynia cordata Thunb. in Pulmonary Fibrosis via Network Pharmacology Analysis."Front Pharmacol. 2021; 12: 733618 5. [IF=5.81] Zhao Yeye et al."Sodium New Houttuyfonate Affects Transcriptome and Virulence Factors of Pseudomonas aeruginosa Controlled by Quorum Sensing."Front Pharmacol. 2020 Oct;0:1581 6. [IF=4.235] Wu Jiadi et al."Sodium New Houttuyfonate Inhibits Candida albicans Biofilm Formation by Inhibiting the Ras1-cAMP-Efg1 Pathway Revealed by RNA-seq."Front Microbiol. 2020 Aug;0:2075 |
Introduction | sodium new houttuyfonate, chemical name: sodium bisulfite adduct of dodecylacetaldehyde, with heat-clearing and detoxifying properties, it has the effects of eliminating abscess and draining pus, diuresis and purgative action. |
function | sodium new houttuyfonate is a broad-spectrum antibacterial drug, which can improve the immunity of the body, pneumonia Diplococcus, E. Coli and spore hyphae have obvious inhibitory effect, for Pneumonia, chronic bronchitis, Upper Respiratory Infections and other respiratory system inflammation, is also used to treat pelvic inflammatory disease, Annex inflammation, chronic cervicitis and other gynecological inflammation. |
preparation | (1) preparation of 2-tridecanone: firstly, add 2.3g of metallic sodium into the reaction bottle, then, 3ml of anhydrous ethanol was added, and the mixture was heated to 25-30 ° C., into which 13.0g of ethyl acetoacetate, 10ml of ethanol and 12.5ml of anhydrous ether were added dropwise, and the mixture was stirred and refluxed for 1 hour; then, 21.85G of lauroyl chloride and 30ml of diethyl ether were added to the reaction flask, and the mixture was stirred and refluxed for 2-3 hours. After cooling, the mixture was dissolved in dilute sulfuric acid, the ether layer was separated, and the aqueous layer was extracted twice with diethyl ether, the organic layers were combined and washed with distilled water, and ether was recovered to obtain 15.7g (yield 92%) of the intermediate 2-tridecone. (2) preparation of dodecylacetaldehyde: Using anhydrous ethanol as solvent, add 1.1g of metal sodium in the reaction vessel, heat reflux for 1 hour, add 8G 2-tridecanone and 3G ethyl formate Dropwise, The reaction was stirred for 4-6 hours, allowed to stand overnight, washed with distilled water, then extracted with ether for several times, the ether solution was combined, dried with anhydrous sodium sulfate, filtered, and finally the ether was separated, dodecylacetaldehyde (8.3g) was obtained in a yield of 90.3%. (3) preparation of sodium a-hydroxydodecanesulfonate: after adding 60ml of saturated sodium bisulfite saturated solution to the reaction vessel, slowly adding 6.9g of dodecylacetaldehyde thereto, 85~90 C reaction for 1.5 hours, temperature, filtration, washing, drying, a-hydroxydodecylethyl sulfonic acid sodium yield of 89.3% G was obtained, the content was 99.4% by HPLC. |