Spirosolan-3-ol, (3beta,5alpha,22beta,25S)-
TOMATIDINE
CAS: 77-59-8
Molecular Formula: C27H45NO2
Spirosolan-3-ol, (3beta,5alpha,22beta,25S)- - Names and Identifiers
Spirosolan-3-ol, (3beta,5alpha,22beta,25S)- - Physico-chemical Properties
| Molecular Formula | C27H45NO2 |
| Molar Mass | 415.65 |
| Density | 1.0048 (rough estimate) |
| Melting Point | 210.5℃ |
| Boling Point | 534.2°C (rough estimate) |
| Specific Rotation(α) | (MeOH)+5 |
| Solubility | Soluble in methanol, ethanol, DMSO and other organic solvents |
| Appearance | Needle crystal |
| pKa | 15.14±0.70(Predicted) |
| Storage Condition | 2-8℃ |
| Refractive Index | 1.6840 (estimate) |
| MDL | MFCD00075644 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from tomato rhizome, leaf, green fruit content is high, low mature fruit. |
| Use | Lycopene has antibacterial, anti-inflammatory, antihistamine, cardiotonic, anticancer effects. Used for content determination/identification/pharmacological experiments, etc. |
Spirosolan-3-ol, (3beta,5alpha,22beta,25S)- - Risk and Safety
| Risk Codes | 23/25 - Toxic by inhalation and if swallowed. |
| Safety Description | S1 - Keep locked up. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | 1544 |
Spirosolan-3-ol, (3beta,5alpha,22beta,25S)- - Upstream Downstream Industry
Spirosolan-3-ol, (3beta,5alpha,22beta,25S)- - Reference
| Reference Show more | Zhou Shiyue, Wang Rui, Shao Yingying, et al. Effects of tomato alkaloid on proliferation, apoptosis and metastasis of colorectal cancer HCT116 cells [J]. Central South pharmacy, 2020, 29 (4). |
Spirosolan-3-ol, (3beta,5alpha,22beta,25S)- - Introduction
bioactive Tomatidine blocks NF-& kappa;B and JNK signals play an anti-inflammatory role. Tomatidine activates autophagy (autophagy) in mammalian cells or in Caenorhabditis elegans.
Target
p65
JNK
In vitro study
Tomatidine decreases inducible NO synthase and COX-2 expression through suppression of I-κBα phosphorylation, NF-κ B nuclear translocation and JNK activation, which in turn inhibits c-jun phosphorylation and Oct-2 expression. Tomatidine, solasodine and diosgenin (40 μM) show 66%, 22% and 41% inhibition of nitrite production, respectively. The iNOS protein is barely detectable in unstimulated cells but markedly increases after LPS treatment, and Tomatidine causes dose-dependent inhibition of LPS-induced iNOS expression. p65 is the major component of NF-κ B in LPS-stimulated macrophages, the effect of Tomatidine on p65 DNA-binding activity is determined. In the presence of Tomatidine at 10-40 μM, the binding activity of NF-κ B is suppressed in a dose-dependent manner. Tomatidine inhibits the phosphorylation of I-κ B, blocks the I-κ B production, and furthermore suppresses p65 NF-κ B translocation to the nucleus and modulated binding activity.
Last Update：2024-04-09 20:52:54
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Spot supply
Product Name: Tomatidine Visit Supplier Webpage Request for quotationCAS: 77-59-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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Raw Materials for Spirosolan-3-ol, (3beta,5alpha,22beta,25S)-