Name | Src Inhibitor 1 |
Synonyms | HHAT MART2 SKI-1 Src-l1 Src I1 Src Inhibitor-1 Src Inhibitor 1 6,7-Dimethoxy-N-(4-phenoxyphenyl)- ANTI-HHAT (N-TERM) antibody produced in rabbit |
CAS | 179248-59-0 |
Molecular Formula | C22H19N3O3 |
Molar Mass | 373.4 |
Solubility | DMSO: >10mg/mL |
Appearance | white powder |
Color | White or off-white |
Storage Condition | 2-8°C |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week. |
In vitro study | Src-I1 is competitive with both ATP and peptide binding sites of the kinase. The IC 50 values are 44 and 88 nM for Src and Lck, respectively. Src-I1, is found to be a potent inhibitor of Src (IC 50 =0.18 μM), but also inhibited other Src family members, such as Lck, Csk and Yes with similar potency to Src, and RIP2 (IC 50 =0.026 μM) with even greater potency. In addition, it inhibited CHK2 with similar potency to Src, and Aurora B with slightly lower potency. |
Hazard Symbols | Xn - Harmful |
Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
UN IDs | UN 3077 9 / PGIII |
WGK Germany | 3 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.678 ml | 13.39 ml | 26.781 ml |
5 mM | 0.536 ml | 2.678 ml | 5.356 ml |
10 mM | 0.268 ml | 1.339 ml | 2.678 ml |
5 mM | 0.054 ml | 0.268 ml | 0.536 ml |