Molecular Formula | C22H36NNaO7S |
Molar Mass | 459.6 |
Density | 1.19±0.1 g/cm3(Predicted) |
Melting Point | 220-2220C |
Solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
Appearance | Solid |
Color | White to Off-White |
pKa | -0.04±0.20(Predicted) |
Storage Condition | -20°C Freezer |
Stability | Hygroscopic |
biological activity | Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) is a long-chain fatty acid that inhibits the transport of fatty acids into cells. Sulfosuccinimidyl oleate is a potent and irreversible inhibitor of the mitochondrial respiratory chain. Sulfosuccinimidyl oleate binds to the CD36 receptor on the surface of microglia. Has an anti-inflammatory effect. |
Cell Line: | BV2 cells BV2 cells |
Concentration: | 20 μM and 50 μM 50 μM |
Incubation Time: | 24 hours 24 hours |
Result: | Did not alter the viability of BV2 cells alone. Exposure of BV2 cells to 100 ng/mL LPS and 5 ng/mL IFNγ significantly reduced the viability of BV2 cells while simultaneous treatment with Sulfosuccinimidyl oleate prevented it. Drastically increased the levels of NOS2, COX-2, and P-p38/T-p38. Reduced brain damage following ischemia. Attenuated infarct size. |
Animal Model: | 4-month-old male BALB/cABom mice with pMCAo model |
Dosage: | 50 mg/kg |
Administration: | Administered once by single oral gavage |