Sulindac Sulfide
SULINDAC SULFIDE
CAS: 49627-27-2
Molecular Formula: C20H17FO2S
Sulindac Sulfide - Names and Identifiers
Sulindac Sulfide - Physico-chemical Properties
| Molecular Formula | C20H17FO2S |
| Molar Mass | 340.41 |
| Melting Point | 189-191°C |
| Solubility | DMSO: >22mg/mL |
| Appearance | solid |
| Color | yellow |
| Storage Condition | -20°C Freezer |
| In vitro study | Treatment with 100 μM of Sulindac sulfide (SSide) causes cell death presumably by inducing apoptosis, resulting in marked decrease in Aβgeneration as well as in total protein expression. The IC 50 value for Aβ42 secretion of Sulindac sulfide is 30.6±2.8 μM. SSone and naproxen have no effect either on Aβ40 or Aβ42 secretion as well as on Notch cleavage up to 100 μM. It is observed that an inhibition of γ 42 -secretase activity by Sulindac sulfide in a dose-dependent manner. The IC 50 value of SSide for inhibiting γ 42 -secretase activity in vitro is 20.2±2.6 μM. A decrease is found in slope by the increase of the concentration of SSide in the plot of rate against the enzyme concentration, suggesting that Sulindac sulfide is not an irreversible or pseudo-irreversible inhibitor. Moreover, when the dialyzed solubilizedγ-secretase fraction is pretreated with Sulindac sulfide against CHAPSO buffer without Sulindac sulfide, γ-secretase activity is almost totally recovered. From these data, it is strongly suggested that the genuine molecular target of Sulindac sulfide is the γ-secretase complex and that Sulindac sulfide works as a reversible γ-secretase inhibitor. |
Sulindac Sulfide - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R42/43 - May cause sensitization by inhalation and skin contact. R63 - Possible risk of harm to the unborn child |
| WGK Germany | 3 |
| HS Code | 2930902000 |
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Spot supply
Product Name: Sulindac Impurity 3(Sulindac EP Impurity C) Visit Supplier Webpage Request for quotationCAS: 49627-27-2
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: Sulindac Sulfide Visit Supplier Webpage Request for quotation
CAS: 49627-27-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 49627-27-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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