T 3775440

Molecular Formula	C18H23ClN4O
Molar Mass	346.86
Storage Condition	Room Temprature
In vitro study	T-3775440 enhances the transdifferentiation of erythrocytes/megakaryocytes into granulocyte-like monocytes. T-3775440 disrupts the interaction of LSD1 and GFI1B. AEL(TF-1a, HEL92.1.7) cells and AMKL(CMK11-5, M07e) cells were treated with T-3775440 for 48 hours, T-3775440 induced cell cycle arrest and apoptosis. In TF-1a and CMK11-5 cells, T-3775440 treatment increased G1 and sub-G1 cells.
In vivo study	In the AML mouse xenograft model, T-3775440 inhibited tumor growth. In mice T-3775440 caused a transient decrease in platelets followed by a large rebound. After a single dose, T-3775440 had no significant effect on the number of red blood cells. In AEL(HEL 92.1.7) model and AMKL(CMK11-5) model, T-3775440 also exert anti-tumor activity.

biological activity	T-3775440 HCl is an irreversible LSD1 inhibitor. It is highly selective for LSD1 relative to other monoamine oxidases with an IC50 of 2.1 nM.
Target	Value
LSD1 ()	2.1 nM

Last Update：2024-04-10 22:29:15

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CAS: 1422535-52-1
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Product Name: T-3775440 hydrochloride Visit Supplier Webpage Request for quotation
CAS: 1422535-52-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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T 3775440

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