TAS 103

Name	TAS-103 (dihydrochloride)
Synonyms	TAS 103 TAS-103(2HCl) BMS-247615-2HCl TAS-103(BMS-247615) BMS247615 dihydrochloride TAS-103 (dihydrochloride) TAS-103 (dihydrochloride) BMS 247615 dihydrochloride BMS-247615 dihydrochloride 6-[[2-(Dimethylamino)ethyl]amino]-3-hydroxy-7H-indeno[2,1-c]quinolin-7-one dihydrochloride
CAS	174634-09-4

Molecular Formula	C20H21Cl2N3O2
Molar Mass	406.30564
Solubility	H₂O: 15.3 mg/mL
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
In vitro study	TAS-103 is a dual inhibitor of DNA topoisomerase I/II. TAS-103 (0.1-10 μM) is active on CCRF-CEM cells, with an IC 50 value of 5 nM. TAS-103 (0.1 μM) significantly increases levels of topo IIα FITC immunofluorescence in individual CCRF-CEM cells. TAS-103 (0.01-1 μM) is highly cytotoxic to Lewis lung carcinoma (LLC) cells, and Liposomal TAS-103 is almost as active as free TAS-103. TAS-103 inhibits the viability of HeLa cells, with an IC 50 of 40 nM. TAS-103 (10 μM) disrupts signal recognition particle (SRP) complex formation, and induces destabilization of SRP14 and SRP19 and its eventual degradation.
In vivo study	TAS-103 (30 mg/kg, i.v.) causes significant tumor growth suppression in mice bearing Lewis lung carcinoma (LLC) cells, without obvious body weight loss, and the liposomal TAS-103 is more active than free TAS-103.

Last Update：2024-01-02 23:10:35

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Product Name: TAS-103 (dihydrochloride) Visit Supplier Webpage Request for quotation
CAS: 174634-09-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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TAS 103

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