Molecular Formula | C41H66O13 |
Molar Mass | 766.95 |
Density | 1.18±0.1 g/cm3(Predicted) |
Boling Point | 854.3±65.0 °C(Predicted) |
Appearance | Solid |
BRN | 3583132 |
pKa | 12.33±0.20(Predicted) |
Storage Condition | −20°C |
Hazard Symbols | T+ - Very toxic |
Risk Codes | 28 - Very Toxic if swallowed |
Safety Description | S22 - Do not breathe dust. S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
UN IDs | UN 3462 6.1/PG 2 |
WGK Germany | 3 |
RTECS | WX1000000 |
FLUKA BRAND F CODES | 3-8-10-21 |
biological activity | Tautomycin is a fungal antibiotic that can be isolated from Streptomyces verticlatus, they are potent specific inhibitors of protein phosphatases 1 and 2A, inducing smooth muscle contraction in the absence of Ca2 with Kiapp values of 0.16 nM and 0.4 nM, respectively. |
Target | Kiapp: 0.16 nM (PP1), 0.4 nM (PP2A). |
Cell Line: | Human MTC cells Human MTC cells |
Concentration: | 0-1000 nM 0-1000 nM |
Incubation Time: | 48 hours 48 hours |
Result: | Inhibited MTC cell growth in a dose-dependent manner. Led to a dose-dependent decrease in the NE markers ASCL1 and CgA. |