TC-G 1005

TC-G 1005 - Names and Identifiers

Name	(4-Cyclopropyl-3,4-dihydro-1(2H)-quinoxalinyl)[4-(2,5-dimethylphenoxy)-3-pyridinyl]methanone
Synonyms	TC-G 1005 (4-Cyclopropyl-3,4-dihydro-1(2H)-quinoxalinyl)[4-(2,5-dimethylphenoxy)-3-pyridinyl]methanone Methanone, (4-cyclopropyl-3,4-dihydro-1(2H)-quinoxalinyl)[4-(2,5-dimethylphenoxy)-3-pyridinyl]-
CAS	1415407-60-1

TC-G 1005 - Physico-chemical Properties

Molecular Formula	C25H25N3O2
Molar Mass	399.48
Density	1.253±0.06 g/cm3(Predicted)
Boling Point	564.5±50.0 °C(Predicted)
Solubility	Soluble in DMSO
pKa	6.35±0.20(Predicted)
Storage Condition	-20℃
Use	TC-G 1005 is a potent and selective TGR5 (GPBAR1) agonist.
Target	IC50: 0.72 nM (hTGR5); 6.2 nM (mTGR5)

TC-G 1005 - Reference

Reference

1: Duan H, Ning M, Chen X, Zou Q, Zhang L, Feng Y, Zhang L, Leng Y, Shen J. Design, synthesis, and antidiabetic activity of 4-phenoxynicotinamide and 4-phenoxypyrimidine-5-carboxamide derivatives as potent and orally efficacious TGR5 agonists. J Med Chem. 2012 Dec 13;55(23):10475-89. doi: 10.1021/jm301071h. Epub 2012 Nov 29. PubMed PMID: 23148522.