Name | 7-hydroxy-2-phenyl-4-benzopyrone |
Synonyms | 7-hydroxyflavone 7-HYDROXYFLAVONE HYDROXYFLAVONE, 7- TIMTEC-BB SBB005921 HYDROXYFLAVONE, 7-(RG) 7-HYDROXY-2-PHENYLCHROMONE 7-hydroxy-2-phenyl-4-benzopyrone 7-hydroxy-2-phenyl-4H-chromen-4-one 7-HYDROXY-2-PHENYL-4H-CHROMEN-4-ONE |
CAS | 6665-86-7 |
EINECS | 229-705-3 |
InChI | InChI=1/C15H10O3/c16-11-6-7-12-13(17)9-14(18-15(12)8-11)10-4-2-1-3-5-10/h1-9,16H |
Molecular Formula | C15H10O3 |
Molar Mass | 238.24 |
Density | 1.340±0.06 g/cm3 (20 ºC 760 Torr) |
Melting Point | 245-247 °C (lit.) |
Boling Point | 320.83°C (rough estimate) |
Flash Point | 176.3°C |
Water Solubility | Insoluble in water |
Vapor Presure | 1.02E-08mmHg at 25°C |
Appearance | powder to crystal |
Color | White to Light yellow |
BRN | 194089 |
pKa | 7.02±0.40(Predicted) |
Storage Condition | 2-8℃ |
Refractive Index | 1.5740 (estimate) |
MDL | MFCD00006835 |
Physical and Chemical Properties | The melting point was 240 °c (-247 °c). The hydroxyl compounds of flavonoids are widely distributed in the plant kingdom in the form of free or glycoside. |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection |
WGK Germany | 3 |
HS Code | 29329990 |
Hazard Note | Irritant |
Reference Show more | 1. Zhang, Cao, et al. "Chemical structures of polyphenols that critically influence the toxicity of ZnO nanoparticles." Journal of agricultural and food chemistry 66.7 (2018): 1714-1722.https://doi.org/10.1021/acs.jafc.8b00368 2. [IF=5.279] Cao Zhang et al."Chemical Structures of Polyphenols That Critically Influence the Toxicity of ZnO Nanoparticles."J Agr Food Chem. 2018;66(7):1714–1722 |
biological activity | 7-Hydroxyflavone is a flavonoid isolated from M. indica and has anti-inflammatory effects. 7-Hydroxyflavone protects kidney cells from nicotine (NIC)-induced cytotoxicity through the ERK/Nrf2/HO-1 pathway. |
Use | as an intermediate for flavonoid selective coronary vasodilators. |
production method | 2, 4-dihydroxyacetophenone was obtained by acetylation of M-phenol acetic acid, the translocation yields (2-hydroxy-4-benzoyloxy) benzoyl acetophenone. It was further cyclized in a mixture of acetic acid and hydrochloric acid at 103 ° C. For about 7H to obtain 7-hydroxyflavone. |