TRI(HYDROXYMETHYL) AMINO METHANE HYDROCHLORIDE
Tri(Hydroxymethyl) Amino Methane Hydrochloride
CAS: 1185-53-1
Molecular Formula: C4H12ClNO3
TRI(HYDROXYMETHYL) AMINO METHANE HYDROCHLORIDE - Names and Identifiers
TRI(HYDROXYMETHYL) AMINO METHANE HYDROCHLORIDE - Physico-chemical Properties
| Molecular Formula | C4H12ClNO3 |
| Molar Mass | 157.6 |
| Density | 1.05 g/mL at 20 °C |
| Melting Point | 150-152℃ |
| Boling Point | 357℃ at 760 mmHg |
| Water Solubility | SOLUBLE |
| Appearance | clear colorless (40 % (w/w) in H2O) solution in crystalline |
| pKa | 8.1(at 25℃) |
| PH | 2.5-4.0 (25℃, 4M in H2O) |
| Storage Condition | Room Temprature |
| Stability | Stable. Incompatible with strong oxidizing agents, bases, moisture. |
| Sensitive | Easily absorbing moisture |
| MDL | MFCD00012590 |
| Use | Used as an intermediate in organic synthesis |
TRI(HYDROXYMETHYL) AMINO METHANE HYDROCHLORIDE - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | TY2900000 |
| FLUKA BRAND F CODES | 3 |
| TSCA | Yes |
| HS Code | 29221980 |
TRI(HYDROXYMETHYL) AMINO METHANE HYDROCHLORIDE - Upstream Downstream Industry
| Downstream Products | Glycine hydrochloride 2,2-DIMETHYL-1,3-DIOXAN-5-ONE |
TRI(HYDROXYMETHYL) AMINO METHANE HYDROCHLORIDE - Reference
| Reference Show more | 1. Chen Wei, Guan Jinping, Kuang Xiaohui, et al. Electrostatic Layer-by-Layer Self-Assembly Flame Retardant Finishing of Dopamine Modified Polyester Cotton [J]. Printing and Dyeing, 2017(2):11-15. 2. Huang Mengming, Tian Peng, Liu Zhanqi, et al. Research on Extraction Technology and Antioxidation Evaluation of New Osmanthus Wine [J]. Food Research and Development, 2019(4). 3. Guan Jinping, Kuang Xiaohui, Tang Rencheng, et al. Functional Finishing of Dopamine Modified Silk Fabric by Ferric Chloride [J]. Journal of Textile, 2019, 40(02):130-134. 4. Liu Xiaoxia, An Xueming, Li Yanhu, et al. Determination of antioxidant components and in vitro antioxidant capacity of soaked vinegar garlic [J]. Journal of Gansu Agricultural University, 2019(4). 5. Zhang Buyue, Wang Wei, Ye Mei, et al. Study on the interaction between cyanine dye and transferrin in different conformations [J]. Guangzhou Chemical Industry, 2019, 047(017):77-80. 6. Liu Jiao, Qu Chongzheng, xie Pingjin, Ye Dalin, Luo Zhen, Liang Zhenghui, Tao Jing, Jiang Ganghui. Changes of Toll-like receptor 4/myeloid differentiation factor 88 signal transduction pathway in knee osteoarthritis model rats after massage treatment [J]. China Organization Engineering Research, 2019,23(19):3019-3024. 7. Wu, Xiaoxuan, et al. "A wearable, self-adhesive, long-lastingly moist and healable epidermal sensor assembled from conductive MXene nanocomposites." Journal of Materials Chemistry C 8.5 (2020): 1788-1795.https://doi.org/10.1039/C9TC05575D 8. Jin, Yanhong, et al. "Ebselen reversibly inhibits human glutamate dehydrogenase at the catalytic site." Assay and drug development technologies 16.2 (2018): 115-122.https://doi.org/10.1089/adt.2017.822 9. Meng Wang, Min Peng, Jiang Zhu, Yi-Dong Li, Jian-Bing Zeng, Mussel-inspired chitosan modified superhydrophilic and underwater superoleophobic cotton fabric for efficient oil/water separation, Carbohydrate Polymers, volume 244, 2020, 116449, ISSN 0144-8617, 10. Zang, Yichao, et al. "Development of a thin-layer chromatography bioautographic say for neuraminidase inhibitors hyphenated with electrostatic field induced spray ionisation-mass spectrometry for identification of active Isatis indigotica root compounds. 11. [IF = 1.62] Xiao-Hui Kuang et al." Surface functionalization of polyamide fiber via dopamine polymerization."Mater Res Express. 2017 Sep;4(9):095302 12. [IF = 9.381] Meng Wang et al." Mussel-inspired chitosan modified superhydrophilic and underwater superoleophobic cotton fabric for efficient oil/water separation."Carbohyd Polym. 2020 Sep;244:116449 13. [IF = 7.393] Xiaoxuan Wu et al." A wearable, self-adhesive, long-lastingly moist and healable epidermal sensor assembled from conductive MXene nanocomposites."J Mater Chem C. 2020 Feb;8(5): 1788-1795 14. [IF = 6.986] Xinyi Liu et al." Multifunctional Nano-Sunflowers with Color-Magnetic-Raman Properties for Multimodal Lateral Flow Immunoassay."Anal Chem. 2021;93(7):3626-3634 15. [IF = 6.119] Peng Jin et al." Efficient bioconversion of high-concentration D-fructose into D-mannose by a novel N-acyl-D-glucosamine 2-epimerase from Thermobifida halotolerans."Ctal Sci Technol. 2021 Mar;11(5):1922-1930 16. [IF = 5.396] Hang Xu et al." The ameliorative effect of the Pyracantha fortuneana (Maxim.) H. L. Li extract on intestinal barrier dysfunction through modulating glycolipid digestion and gut microbiota in high fat diet-fed rats."Food Funct. 2019 Oct;10(10):6517-6532 17. [IF = 4.759] yichao Zhang et al." Development of a thin-layer chromatography bioautographic say for neuraminidase inhibitors hyphenated with electrostatic field induced spray ionisation-mass spectrometry for identification of active Isatis indigotica root compounds."J 18. [IF = 6.475] Tao-Tao Xue et al." Evaluation of antioxidant, enzyme inhibition, nitric oxide production inhibitory activities and chemical profiles of the active extracts from the medicinal and editor plant: Althaea officinalis."Food Res Int. 2022 Jun;156:111166 19. [IF = 4.539] Hao Chen et al." Ultralow friction polymer composites containing high dispersed and thermally rob microcapsules."Colloid Surface A. 2022 Feb;634:127989 20. [IF = 5.833] Song Yongxin et al." Photothermal-enhanced peroxidase-like activity of CDs/PBNPs for the detection of Fe3 and cholesterol in series samples."Microchim Acta. 2022 Jan;189(1):1-14 |
TRI(HYDROXYMETHYL) AMINO METHANE HYDROCHLORIDE - Uses and synthesis methods
Introduction
Trimethylolaminomethane hydrochloride is abbreviated as Tris-HCl. Trihydroxymethyl aminomethane hydrochloride buffer (Tris-HCl buffer) is not only widely used as a solvent for nucleic acids and proteins, but also has many important uses.
application
Tris-HCl are used for protein crystal growth under different pH conditions. The low ionic strength characteristics of Tris-HCL buffer can be used for the formation of intermediate fibers of nematode (C. elegans) nuclear lamin. Tris-HCl is also one of the main components of protein electrophoresis buffer. In addition, Tris-HCL is also an intermediate for preparing surfactants, vulcanization accelerators and some drugs. Tris-HCl are also used as titration standards.
Buffer solution preparation
trimethylolaminomethane hydrochloride was used as solute, deionized water was used as solvent, and HCl aqueous solution with concentration of 0.1mol/L was used to adjust pH value to prepare trimethylolaminomethane hydrochloride buffer solution (Tris-HCl buffer solution) with concentration of 6.057g/L and pH = 8.8.
chemical properties
White crystals.
Use
The pH of all buffers depends on temperature and concentration. For Tris buffer, the temperature increases by about 0.03 units for every 1°C pH increase, and the dilution pH decreases by 0.03-0.05 units for every 10 times.
For biological buffer
Used as an intermediate in organic synthesis
Last Update：2023-08-16 22:24:45
TRI(HYDROXYMETHYL) AMINO METHANE HYDROCHLORIDE - Nature
| melting point | 150-152 °C |
| density | 1.05 g/mL at 20 °C |
| storage conditions | room temp |
| solubility | H2O: 4 M at 20 °C, clear, colorless |
| morphology | crystalline |
| color | clear colorless (40 % (w/w) in H2O) solution |
| PH value | 2.5-4.0 (25℃, 4M in H2O) |
| pH range of acid-base indicator discoloration | 7.0 - 9.0 |
| acidity coefficient (pKa) | 8.1(at 25℃) |
| water solubility | SOLUBLE |
| maximum wavelength (& lambda;max) | λ: 260 nm Amax: 0.12 λ: 280 nm Amax: 0.08 |
| sensitivity | Hygroscopic |
| BRN | 3675235 |
| stability | Stable. Incompatible with strong oxidizing agents, bases, moisture. |
| InChIKey | QKNYBSVHEMOAJP-UHFFFAOYSA-N |
| EPA chemical information | 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride (1185-53-1) |
Last Update：2024-04-10 22:29:15
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View History
TRI(HYDROXYMETHYL) AMINO METHANE HYDROCHLORIDE
2-Butenoic acid, 2-methyl-, 3-phenyl-2-propen-1-yl ester, (2E)-
2-(二苯基膦基)乙胺
2-Butenoic acid, 2-methyl-, 3-phenyl-2-propen-1-yl ester, (2E)-
2-(二苯基膦基)乙胺
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