Name | triamcinolone hexacetonide |
Synonyms | tatba C08185 Triamcinolone hexatonide TRIAMCINOLONE HEXACETONIDE triamcinolone hexacetonide Triamcinolone Hexaacetonide TRIAMCINOLONEHEXACETONIDE,USP lic16,17-acetalwithacetone,21-(3,3-dimethylbutyrate) 9-Fluoro-11β,21-dihydroxy-16α,17-(isopropylidenebisoxy)pregna-1,4-diene-3,20-dione 21-(3,3-dimethylbutyrate) 21-(3,3-Dimethyl-1-oxobutoxy)-9-fluoro-11β-hydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione |
CAS | 5611-51-8 |
EINECS | 227-031-4 |
InChI | InChI=1/C30H41FO7/c1-25(2,3)15-24(35)36-16-22(34)30-23(37-26(4,5)38-30)13-20-19-9-8-17-12-18(32)10-11-27(17,6)29(19,31)21(33)14-28(20,30)7/h10-12,19-21,23,33H,8-9,13-16H2,1-7H3/t19-,20-,21-,23+,27-,28-,29-,30+/m0/s1 |
Molecular Formula | C30H41FO7 |
Molar Mass | 532.64 |
Density | 1.1277 (estimate) |
Melting Point | 295-296° (dec); mp 271-272° (dec) |
Boling Point | 619.5±55.0 °C(Predicted) |
Specific Rotation(α) | D25 +90±2° (c = 1.13% in chloroform) |
Flash Point | 328.5°C |
Solubility | Practically insoluble in water, sparingly soluble in anhydrous ethanol and in methanol. |
Vapor Presure | 6.1E-18mmHg at 25°C |
Appearance | neat |
Color | Fine, white, needle-like crystals |
pKa | 13.09±0.70(Predicted) |
Storage Condition | 2-8°C |
Refractive Index | 1.556 |
In vivo study | Triamcinolone hexacetonide produces a marked, dose-dependent protective effect in the model of chemically induced articular cartilage damage. Guinea pig injected with Triamcinolone hexacetonide shows much less prominent fibrillation and osteophytes. Cell loss is less extensive. A single injection of Triamcinolone hexacetonide into the ipsilateral knee of rabbits which have been subjected to partial lateral meniscectomy and transection of the sesamoid and collateral fibular ligaments reduces chondrocyte cloning, loss of cells, osteophyte formation, and fibrillation. The half-life of commercially available Triamcinolone hexacetonide in the vitreous is double that of Triamcinolone hexacetonide, but the former is toxic to the retina in this rabbit model. Reformulated iso-osmolar Triamcinolone hexacetonide shows no evidence of deleterious effects to retina function or structure. Local application of Triamcinolone hexacetonide at a site of lingual nerve injury leads to changes that are potentially beneficial such as reduced mechanical sensitivity and enhanced regeneration. |
WGK Germany | 3 |
HS Code | 2937220000 |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
biological activity | Triamcinolone hexacetonide is a commonly used long-acting steroid with potential for subacute and chronic inflammatory joint diseases. |
category | toxic substances |
flammability hazard characteristics | combustible; combustion produces toxic fluoride smoke |
storage and transportation characteristics | warehouse ventilation and low temperature drying |
fire extinguishing agent | dry powder, foam, sand, carbon dioxide, mist water |