Temocapril hydrochloride
Temocapril hydrochloride
CAS: 110221-44-8
Molecular Formula: C23H28N2O5S2.ClH
Temocapril hydrochloride - Names and Identifiers
| Name | Temocapril hydrochloride |
| Synonyms | CS-622 Acecol TemocarpileHCL Temocapril Hcl Temocarpilhydrochloride Temocapril hydrochloride TEMOCAPRIL HYDROCHLORIDE Temocapril HCl and intermediates [(2S,6R)-6-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-5-oxo-2-(thiophen-2-yl)-1,4-thiazepan-4-yl]acetic acid (2S,6R)-6-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-1,4-thiazepine-4(5H)-acetic Acid Hydrochloride 1,4-Thiazepine-4(5H)-acetic acid, 6-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, monohydrochloride, [2S-[2a,6b(R*)]]- 1,4-Thiazepine-4(5H)-acetic acid, 6-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, monohydrochloride, (2S,6R)- (9CI) |
| CAS | 110221-44-8 |
| EINECS | 1312995-182-4 |
| InChI | InChI=1/C23H28N2O5S2/c1-2-30-23(29)17(11-10-16-7-4-3-5-8-16)24-18-15-32-20(19-9-6-12-31-19)13-25(22(18)28)14-21(26)27/h3-9,12,17-18,20,24H,2,10-11,13-15H2,1H3,(H,26,27)/t17-,18-,20-/m0/s1 |
Temocapril hydrochloride - Physico-chemical Properties
| Molecular Formula | C23H28N2O5S2.ClH |
| Molar Mass | 513.076 |
| Density | 1.33g/cm3 |
| Melting Point | 196-2000C (dec) |
| Boling Point | 717.4°C at 760 mmHg |
| Specific Rotation(α) | 25D +47.7° (c = 1 in DMF) |
| Flash Point | 387.7°C |
| Solubility | DMF (Slightly), DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 1.34E-21mmHg at 25°C |
| Appearance | Solid |
| Color | White to Off-White |
| Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
| Refractive Index | 1.628 |
| In vitro study | Temocapril hydrochloride is a prodrug of the ACE inhibitor, Temocaprilat. Temocapril hydrochloride can be readily uptaken via the human small intestine, and then be converted to its active metabolite (temocaprilat) by CES1 in the liver. |
| In vivo study | Temocapril hydrochloride (30 mg/kg; p.o.; daily; for 4 weeks) suppresses Angiotensin I-induced hypertension, plasma and renal ACE activity, but fails to reduce the level of Ang II in the kidney. Animal Model: Male Sprague Dawley rats Dosage: 30 mg/kg Administration: Oral administration, daily, for 4 weeks Result: Suppressed the blood pressure elevation induced by Ang I. |
Temocapril hydrochloride - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| Toxicity | LD50 in mice, rats, dogs (mg/kg): >5000, >5000, >800 orally (Koike) |
Temocapril hydrochloride - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.532 ml | 7.66 ml | 15.32 ml |
| 5 mM | 0.306 ml | 1.532 ml | 3.064 ml |
| 10 mM | 0.153 ml | 0.766 ml | 1.532 ml |
| 5 mM | 0.031 ml | 0.153 ml | 0.306 ml |
Last Update：2024-01-02 23:10:35
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