Tetra-n-butylammonium bromide
Tetrabutylammonium bromide
CAS: 1643-19-2;10549-76-5
Molecular Formula: C16H36NBr
Tetra-n-butylammonium bromide - Names and Identifiers
Tetra-n-butylammonium bromide - Physico-chemical Properties
| Molecular Formula | C16H36NBr |
| Molar Mass | 322.37 |
| Density | 1.039 g/mL at 25 °C |
| Melting Point | 100-104℃ |
| Boling Point | 102 °C |
| Flash Point | 100℃ |
| Water Solubility | 600 g/L (20℃) |
| Solubility | Soluble in ethanol |
| Appearance | Shape Crystalline Powder, color White to slightly cream |
| Storage Condition | Store below +30°C. |
| Stability | Stable. Incompatible with strong oxidizing agents. Protect from moisture. |
| Sensitive | Easily absorbing moisture |
| Refractive Index | n20/D 1.422 |
| MDL | MFCD00011633 |
| Physical and Chemical Properties | melting point 100-104°C |
| Use | Ion-pair reagents for the synthesis of ampicillin, sultamillin, etc. |
Tetra-n-butylammonium bromide - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 3 |
| TSCA | Yes |
| HS Code | 29239000 |
Tetra-n-butylammonium bromide - Upstream Downstream Industry
Tetra-n-butylammonium bromide - Reference
| Reference Show more | 1. Peng Xianglian, Cai Baolin, Fu Hongjun. Study on Separation and Purification of Citral from Litsea cuba Essential Oil [J]. Forest Products Industry, 2018, v.45;No.276(08):21-26. 2. Jiang Xingcan, Li Bing, Yang Min, Zhang Jiyu. Characterization of sarafloxacin/β-cyclodextrin inclusion compound microcapsules [J]. Journal of Animal Husbandry and Veterinary Medicine, 2020,51(08):1993-2002. 3. Guo Qingying, Liu Min, Zhao Yanna, et al. Spectroscopy and Cytotoxicity Study on the Interaction between Daunorubicin and Human Serum Albumin [J]. Spectroscopy and Spectral Analysis, 2020, 040(006):1821-1827. 4. Jiang Xingcan, Li Bing, Zhang Jiyu. Characterization and cytotoxicity of sarafloxacin/β-cyclodextrin inclusion compound [J]. Heilongjiang Animal Husbandry and Veterinary, 2020(24):129-133 177. 5. Jiang Xingcan, Li Bing, Yang Min, Zhang Jiyu. Characterization of sarafloxacin/β-cyclodextrin inclusion compound microcapsules [J]. Journal of Animal Husbandry and Veterinary Medicine, 2020,51(08):1993-2002. 6. [IF = 5.645] Tingting Cai et al."Synthesis of bio-based Cyclic carbonate from vegetable oil methyl ester by CO2 fixation with acid-base pair MOFs." Ind Crop Prod. 2020 Mar;145:112155 7. [IF = 4.098] Qingying Guo et al."Spectroscopic and cytotoxicity studies on the combined interaction of (−)-epigallocatechin-3-gallate and anthracycline drugs with human serum albumin." Spectrochim Acta A. 2019 Nov;222:117213 |
Tetra-n-butylammonium bromide - Introduction
Easy to absorb moisture. It's irritating. There is still a concentrated solution in the commodity.
Last Update：2022-10-16 17:14:15
Tetra-n-butylammonium bromide - Security information
| WGK Germany | 3 |
| F | 3 |
| Hazard Note | Irritant |
| TSCA | Yes |
| customs code | 29239000 |
Last Update：2024-04-10 22:29:15
Tetra-n-butylammonium bromide - Nature
| storage conditions | Store below 30°C. |
| solubility | H2O: 0.1 g/mL, clear, colorless |
| morphology | Crystalline Powder |
| color | White to slightly cream |
| Specific gravity | 1.007 |
| Odor | Amine like |
| water solubility | 600 g/L (20 °C) |
| maximum wavelength (& lambda;max) | λ: 240 nm Amax: 0.04 λ: 250 nm Amax: 0.03 λ: 260 nm Amax: 0.02 λ: 500 nm Amax: 0.02 |
| sensitivity | Hygroscopic |
| BRN | 3570983 |
| stability | Stable. Incompatible with strong oxidizing agents. Protect from moisture. |
| InChIKey | JRMUNVKIHCOMHV-UHFFFAOYSA-M |
| NIST chemical information | Tetra-N-butylammonium bromide(1643-19-2) |
| EPA chemical information | Tetrabutylammonium bromide (1643-19-2) |
Last Update：2024-04-09 21:04:16
Tetra-n-butylammonium bromide - Uses and synthesis methods
introduction
Tetrabutyl ammonium bromide is a common chemical product on the market. It is an ion-pair reagent and an effective phase transfer catalyst.
physical and chemical properties
Tetrabutyl ammonium bromide is also known as tetrabutyl ammonium bromide. White crystal, deliquescent. Melting point 118 ℃. Easily soluble in water, alcohol, ether and acetone, slightly soluble in benzene.
application
Tetrabutyl ammonium bromide is used as an organic chemical phase transfer catalyst for the synthesis of drug intermediates such as benzyltriethylammonium chloride, ethyl cinnamate, pseudoiosterone, and also used for anti-infective drugs The synthesis of organic drugs such as ampicillin and sultaxicillin, tetrabutyl ammonium bromide is also used as a catalyst in the synthesis of the new mechanism of action of the anti-diabetic drug dapaglifloz.
Preparation method
(1) Tetrabutyl ammonium bromide synthesis reaction To a 1000 ml reactor with heating device, electric stirring, thermometer, and water circulation condenser, put 200 grams of tri-n-butylamine, 200 grams of bromobutane, 200 grams of solvent acetonitrile, stir and heat to slow reflux, and react at a constant temperature for 22-24 hours;
(2) crude tetrabutyl ammonium bromide is prepared. the mixture obtained after the reaction is distilled at normal pressure, acetonitrile and excess bromobutane are recovered, heated to 100 ℃, and residual acetonitrile and bromobutane are removed under reduced pressure. the light yellow transparent liquid obtained is crude tetrabutyl ammonium bromide.
Toxicity information
use
1. Used as an intermediate in organic synthesis, phase transfer catalyst
2, ion pair reagent, used for the synthesis of butampicillin, sultamicillin, etc.
3, ion pair chromatography reagent, phase transfer catalyst. Synthesis of Bampicillin, Sultamicillin, etc.
4. Phase transfer catalyst; polarographic analysis reagent; ion pair chromatography reagent
Last Update：2024-04-09 19:04:55
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View History
Downstream Products for Tetra-n-butylammonium bromide
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H-GLY-AMC HBR
FENOTHIOCARB
Venlafaxine hydrochloride
Thianaphthene-2-carboxylic acid
5-Bromobenzo[c]thiophene
Sisthsne
1-(3-Aminopropyl)piperidine
Phenyl vinyl sulfone
CYCLANILIDE
2-(4-ETHOXYPHENYL)-2-METHYL PROPIONITRILE
Levetiracetam
DIOCTYL ETHER
Zeolite
4-(tert-Butyl)benzyl mercaptan