Tetra-n-butylammonium bromide

Tetra-n-butylammonium bromide - Names and Identifiers

Name	Tetrabutylammonium bromide
Synonyms	TBAB (ACS) Tetrabutyl IPC-TBA-BR TBA Bromide aliquat 100 ALIQUAT(R) 100 Tetrabutylammonium bromide Tetra-n-butylammonium bromide TetraButylAmmoniumBromideTbab TETRABUTYLAMMONIUM BROMIDE REAGEN TETRABUTYLAMMONIUM BROMIDE SOLUTION n,n,n-tributyl-1-butanaminiubromide N,N,N-tributylbutan-1-aminium azide TETRABUTYLAMMONIUM BROMIDE, FOR IPC N,N,N-tributylbutan-1-aminium iodide N,N,N-tributylbutan-1-aminium nitrate N,N,N-tributylbutan-1-aminium bromide TetraButylAmmoniumBromideForSynthesis N,N,N-tributylbutan-1-aminium fluoride N,N,N-tributylbutan-1-aminium chloride N,N,N-tributylbutan-1-aminium hydroxide 1-Butanaminium, N,N,N-tributyl-, bromide N,N,N-tributylbutan-1-aminium perchlorate N,N,N-tributylbutan-1-aminium hydrogen sulfate N,N,N-tributylbutan-1-aminium dihydrogen phosphate TETRABUTYLAMMONIUM BROMIDE, ELECTRO-CHEM ICAL GRADE
CAS	1643-19-2 10549-76-5
EINECS	216-699-2
InChI	InChI=1/C16H36N.N3/c1-5-9-13-17(14-10-6-2,15-11-7-3)16-12-8-4;1-3-2/h5-16H2,1-4H3;/q+1;-1
InChIKey	JRMUNVKIHCOMHV-UHFFFAOYSA-M

Tetra-n-butylammonium bromide - Physico-chemical Properties

Molecular Formula	C16H36NBr
Molar Mass	322.37
Density	1.039 g/mL at 25 °C
Melting Point	100-104℃
Boling Point	102 °C
Flash Point	100℃
Water Solubility	600 g/L (20℃)
Solubility	Soluble in ethanol
Appearance	Shape Crystalline Powder, color White to slightly cream
Storage Condition	Store below +30°C.
Stability	Stable. Incompatible with strong oxidizing agents. Protect from moisture.
Sensitive	Easily absorbing moisture
Refractive Index	n20/D 1.422
MDL	MFCD00011633
Physical and Chemical Properties	melting point 100-104°C water-soluble 600g/L (20°C)
Use	Ion-pair reagents for the synthesis of ampicillin, sultamillin, etc.

Tetra-n-butylammonium bromide - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection
WGK Germany	3
FLUKA BRAND F CODES	3
TSCA	Yes
HS Code	29239000

Tetra-n-butylammonium bromide - Upstream Downstream Industry

Downstream Products

1-BENZOTHIOPHENE-5-CARBOXYLIC ACID
Albendazole
Piperonyl aldehyde
3-AMINOBIPHENYL
5-Bromoindazole
ETHYL 4-ETHOXYPHENYLACETATE
H-GLY-AMC HBR
1-Phenylcyclopentanecarboxylic acid
3-PHENYLBENZYLAMINE
4-PYRIDIN-2-YLISOXAZOL-5-AMINE
cintofen
FENOTHIOCARB
(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol
Isocarbophos
Venlafaxine hydrochloride
1-BENZOTHIOPHENE-5-CARBONITRILE
N-(4-THIOPHEN-2-YL-PHENYL)-ACETAMIDE
Thianaphthene-2-carboxylic acid
Myclobutanil
alpha-butyl-alpha-phenyl-1H-imidazole-1-propiononitrile
5-Bromobenzo[c]thiophene
Olaquindox
Sisthsne
2-[2-(DIPHENYLPHOSPHINO)ETHYL]PYRIDINE
Glyceryl monostearate
1-(3-Aminopropyl)piperidine
Phenyl vinyl sulfone
6-Bromopurine
Methyl 3,4,5-trimethoxybenzoate
CYCLANILIDE
2-(4-ETHOXYPHENYL)-2-METHYL PROPIONITRILE
Levetiracetam
4-Bromo-7-azaindole
DIOCTYL ETHER
1,1-Cyclopropanedicarboxylic acid dimethyl ester
2 -phenyl-Hexanenitrile
Zeolite
Tetrabutylammonium hexafluorophosphate
4-(tert-Butyl)benzyl mercaptan
Tetrabutylammonium borohydride

Tetra-n-butylammonium bromide - Reference

Reference

1. Peng Xianglian, Cai Baolin, Fu Hongjun. Study on Separation and Purification of Citral from Litsea cuba Essential Oil [J]. Forest Products Industry, 2018, v.45;No.276(08):21-26.
2. Jiang Xingcan, Li Bing, Yang Min, Zhang Jiyu. Characterization of sarafloxacin/β-cyclodextrin inclusion compound microcapsules [J]. Journal of Animal Husbandry and Veterinary Medicine, 2020,51(08):1993-2002.
3. Guo Qingying, Liu Min, Zhao Yanna, et al. Spectroscopy and Cytotoxicity Study on the Interaction between Daunorubicin and Human Serum Albumin [J]. Spectroscopy and Spectral Analysis, 2020, 040(006):1821-1827.
4. Jiang Xingcan, Li Bing, Zhang Jiyu. Characterization and cytotoxicity of sarafloxacin/β-cyclodextrin inclusion compound [J]. Heilongjiang Animal Husbandry and Veterinary, 2020(24):129-133 177.
5. Jiang Xingcan, Li Bing, Yang Min, Zhang Jiyu. Characterization of sarafloxacin/β-cyclodextrin inclusion compound microcapsules [J]. Journal of Animal Husbandry and Veterinary Medicine, 2020,51(08):1993-2002.
6. [IF = 5.645] Tingting Cai et al."Synthesis of bio-based Cyclic carbonate from vegetable oil methyl ester by CO2 fixation with acid-base pair MOFs." Ind Crop Prod. 2020 Mar;145:112155
7. [IF = 4.098] Qingying Guo et al."Spectroscopic and cytotoxicity studies on the combined interaction of (−)-epigallocatechin-3-gallate and anthracycline drugs with human serum albumin." Spectrochim Acta A. 2019 Nov;222:117213

Tetra-n-butylammonium bromide - Introduction

Easy to absorb moisture. It's irritating. There is still a concentrated solution in the commodity.

Last Update：2022-10-16 17:14:15

Tetra-n-butylammonium bromide - Security information

WGK Germany	3
F	3
Hazard Note	Irritant
TSCA	Yes
customs code	29239000

Last Update：2024-04-10 22:29:15

Tetra-n-butylammonium bromide - Nature

storage conditions	Store below 30°C.
solubility	H2O: 0.1 g/mL, clear, colorless
morphology	Crystalline Powder
color	White to slightly cream
Specific gravity	1.007
Odor	Amine like
water solubility	600 g/L (20 °C)
maximum wavelength (& lambda;max)	λ: 240 nm Amax: 0.04 λ: 250 nm Amax: 0.03 λ: 260 nm Amax: 0.02 λ: 500 nm Amax: 0.02
sensitivity	Hygroscopic
BRN	3570983
stability	Stable. Incompatible with strong oxidizing agents. Protect from moisture.
InChIKey	JRMUNVKIHCOMHV-UHFFFAOYSA-M
NIST chemical information	Tetra-N-butylammonium bromide(1643-19-2)
EPA chemical information	Tetrabutylammonium bromide (1643-19-2)

Last Update：2024-04-09 21:04:16

Tetra-n-butylammonium bromide - Uses and synthesis methods

introduction

Tetrabutyl ammonium bromide is a common chemical product on the market. It is an ion-pair reagent and an effective phase transfer catalyst.

physical and chemical properties

Tetrabutyl ammonium bromide is also known as tetrabutyl ammonium bromide. White crystal, deliquescent. Melting point 118 ℃. Easily soluble in water, alcohol, ether and acetone, slightly soluble in benzene.

application

Tetrabutyl ammonium bromide is used as an organic chemical phase transfer catalyst for the synthesis of drug intermediates such as benzyltriethylammonium chloride, ethyl cinnamate, pseudoiosterone, and also used for anti-infective drugs The synthesis of organic drugs such as ampicillin and sultaxicillin, tetrabutyl ammonium bromide is also used as a catalyst in the synthesis of the new mechanism of action of the anti-diabetic drug dapaglifloz.

Preparation method

(1) Tetrabutyl ammonium bromide synthesis reaction To a 1000 ml reactor with heating device, electric stirring, thermometer, and water circulation condenser, put 200 grams of tri-n-butylamine, 200 grams of bromobutane, 200 grams of solvent acetonitrile, stir and heat to slow reflux, and react at a constant temperature for 22-24 hours;

(2) crude tetrabutyl ammonium bromide is prepared. the mixture obtained after the reaction is distilled at normal pressure, acetonitrile and excess bromobutane are recovered, heated to 100 ℃, and residual acetonitrile and bromobutane are removed under reduced pressure. the light yellow transparent liquid obtained is crude tetrabutyl ammonium bromide.

Toxicity information

use

1. Used as an intermediate in organic synthesis, phase transfer catalyst

2, ion pair reagent, used for the synthesis of butampicillin, sultamicillin, etc.

3, ion pair chromatography reagent, phase transfer catalyst. Synthesis of Bampicillin, Sultamicillin, etc.

4. Phase transfer catalyst; polarographic analysis reagent; ion pair chromatography reagent

Last Update：2024-04-09 19:04:55

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