Tos-L-Lys-CMK·HCl
TLCK
CAS: 4272-74-6
Molecular Formula: C14H22Cl2N2O3S
Tos-L-Lys-CMK·HCl - Names and Identifiers
Tos-L-Lys-CMK·HCl - Physico-chemical Properties
| Molecular Formula | C14H22Cl2N2O3S |
| Molar Mass | 369.31 |
| Melting Point | ~165°C (dec.) |
| Solubility | H2O: 50mg/mL |
| Appearance | powder |
| Color | white to pink |
| BRN | 7106867 |
| Storage Condition | -20°C |
| MDL | MFCD00065395 |
| In vitro study | N-alpha-Tosyl-L-lysine chloromethyl ketone exhibits an inhibitory effect on IFN-γ activities. The effect of TLCK is studied on the IFN-γ sensitization of HeLa cells towards cell death mediated by anti-Fas. Lower concentration of anti-Fas (10 ng/mL) are used to examine the interaction among the three effectors simultaneously, that is, anti-Fas, TLCK and IFN-γ. TLCK by itself up to 50 μM concentration exhibits a small decrease in cell viability. Beyond 50 μM, a dose dependent decrease in cell viability is observed. IFN-γ slightly reduces cell viability on its own. Addition of anti-Fas (10 ng/mL) results in a slight decrease in cell survival, which is enhanced more than additively in the presence of TLCK, most prominently between 50 and 100 μM. Upon addition of both anti-Fas and IFN-γ, a decrease (≈46%) in cell viability is observed. Moreover, the decrease in cell survival is further enhanced upon addition of higher concentrations of TLCK, 25 μM and more. |
Tos-L-Lys-CMK·HCl - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | UN 3335 |
| WGK Germany | 3 |
| RTECS | XT5160000 |
| FLUKA BRAND F CODES | 10-21 |
| HS Code | 29350090 |
Tos-L-Lys-CMK·HCl - Reference Information
| biological activity | N-alpha-Tosyl-L-lysine chloromethyl ketone (TLCK) is a trypsin-like protease inhibitor that sensitizes HeLa cells to Fas-mediated cell death. |
Last Update：2024-04-10 22:29:15
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Product Name: TLCK Visit Supplier Webpage Request for quotationCAS: 4272-74-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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