Trimethylsilylacetic acid methyl ester

Trimethylsilylacetic acid methyl ester - Names and Identifiers

Name	methyl (trimethylsilyl)acetate
Synonyms	METHYLTRIMETHYLSILICATE Methyl trimethylsilylacetate methyl (trimethylsilyl)acetate METHYL (TRIMETHYLSILYL)ACETATE Methyl 2-(triMethylsilyl)acetate Trimethylsilylacetic acid methyl ester 2-(Trimethylsilyl)acetic acid methyl ester Acetic acid, 2-(trimethylsilyl)-, methyl ester 2-[Dimethyl(methyl)silyl]acetic acid methyl ester
CAS	2916-76-9
EINECS	220-845-0
InChI	InChI=1/C6H14O2Si/c1-8-6(7)5-9(2,3)4/h5H2,1-4H3

Trimethylsilylacetic acid methyl ester - Physico-chemical Properties

Molecular Formula	C6H14O2Si
Molar Mass	146.26
Density	0.891g/mLat 25°C(lit.)
Boling Point	38-39°C13mm Hg(lit.)
Flash Point	91°F
Vapor Presure	6.02mmHg at 25°C
Specific Gravity	0.890
BRN	1098961
Storage Condition	Flammables area
Sensitive	2: reacts with aqueous acid
Refractive Index	n20/D 1.414(lit.)

Trimethylsilylacetic acid methyl ester - Risk and Safety

Risk Codes	R11 - Highly Flammable R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
UN IDs	UN 3272 3/PG 3
WGK Germany	3
FLUKA BRAND F CODES	10-21
TSCA	No
HS Code	29319090
Hazard Class	3.1
Packing Group	II

Trimethylsilylacetic acid methyl ester - Introduction

Methyl trimethylsilylacetate is an organic compound with the chemical formula C7H16O2Si. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: colorless liquid
-Solubility: Soluble with organic solvents (such as ethers, alcohols and chlorinated hydrocarbons), insoluble in water
-Boiling point: about 87-89 ° C
-Density: approx. 0.78g/cm³

Use:
-Trimethylsilylacetic acid methyl ester is an important organic synthesis compound, often used as a reagent and intermediate.
-It can be used for deprotection reactions in organic synthesis, such as deprotection of esters.
-can also be used as a solvent and reaction substrate in organic synthesis.

Method:
The preparation of methyl trimethylsilylacetate can generally be carried out by the following steps:
1. First, methyl chloroformate (methyl chloroformate) is reacted with trimethylchlorosilane (trimethylchlorosilane) to obtain trimethylsilyl chloroacetate (trimethylsilyl chloroacetate).
2. Then, under the catalysis of alkali, methyl trimethylsilylchloroacetate is reacted with alcohol to generate methyl trimethylsilylacetate.

Safety Information:
-Trimethylsilyl methyl acetate can cause eye and skin irritation, so avoid contact with skin and eyes when in contact.
-It should be kept away from high temperatures, open flames and oxidants.
-When handling, please wear appropriate protective gloves and eye protection.
-In case of contact, immediately flush the affected area with plenty of water and seek medical help.

Last Update：2024-04-10 22:29:15