Um-792

Name	Naltrexone
Synonyms	Um-792 celupan En 1639A Naltrexone 16590-41-3 Naltrexone (controlled) HCl 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one 3,14-Dihydroxy-17-(cyclopropylmethyl)-4,5α-epoxymorphinan-6-one (5a)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one 17-(cyclopropylmethyl)-4,5-alpha-epoxy-3,14-dihydroxy-morphinan-6-on 5-epoxy-3,14-dihydroxy-17-(cyclopropylmethyl)-(5-alpha)-morphinan-6-on (5alpha)-17-(Cyclopropylmethyl)-3,14-dihydroxy-4,5-epoxymorphinan-6-one (4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one (1S,5R,13R,17S)-4-(Cyclopropylmethyl)-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.0~1,13~.0~5,17~.0~7,18~]octadeca-7(18),8,10-trien-14-on (1S,5R,13R,17S)-4-(cyclopropylméthyl)-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.0~1,13~.0~5,17~.0~7,18~]octadéca-7(18),8,10-trién-14-one (1S,5R,13R,17S)-4-(cyclopropylmethyl)-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.0~1,13~.0~5,17~.0~7,18~]octadeca-7(18),8,10-trien-14-one
CAS	16590-41-3
EINECS	240-649-9
InChI	InChI=1/C20H23NO4/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11/h3-4,11,15,18,22,24H,1-2,5-10H2/t15-,18+,19?,20-/m1/s1

Molecular Formula	C20H23NO4
Molar Mass	341.4
Density	1.2064 (rough estimate)
Melting Point	168-170°
Boling Point	477.03°C (rough estimate)
Flash Point	9℃
Solubility	Chloroform (Slightly), Methanol (Slightly)
Vapor Presure	2.71E-13mmHg at 25°C
Appearance	Solid
Color	White to Light Beige
pKa	pKa 8.38/8.13(H2O,t =20/37,I
Storage Condition	2-8°C
Refractive Index	1.5614 (estimate)

Risk Codes	R11 - Highly Flammable R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R39/23/24/25 -
Safety Description	S16 - Keep away from sources of ignition. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	1
HS Code	2939190000
Toxicity	LD50 in mice (mg/kg): 586 s.c. (Maickel)

EPA chemical substance information	information provided by: ofmpeb.epa.gov (external link)
pharmacological action	Naltrexone, the chemical structure of which is 17-cyclopropylmethyl -4, 5A-epoxy -3,14-dihydroxymorphone -6-one. Without tolerance and addiction, it is a pure opioid antagonist, which can block the intravenous injection of opioids (such as heroin, etc.) by competitive binding at the opioid receptor site. Pharmacological Efficacy. And naltrexone can make the patient in vivo opioid receptor system hypersensitivity effect or up-regulation, so as to alleviate the elimination of chronic withdrawal reaction, reduce the relapse rate. Therefore, naltrexone is the only drug at home and abroad to consolidate the efficacy and anti-relapse of opioid addicts after detoxification.
adverse reactions	Nausea, Abdominal Pain, rash. Should be used with caution in patients with liver dysfunction.
category	toxic substances
toxicity grade	high toxicity
Acute toxicity	subcutaneous-mouse LD50: 551 mg/kg
flammability hazard characteristics	flammable; Thermal decomposition of toxic NOx fumes
storage and transportation characteristics	The warehouse is ventilated and dried at low temperature; It is stored and transported separately from oxidant and food
fire extinguishing agent	water, sand, foam
toxic substance data	information provided by: pubchem.ncbi.nlm.nih.gov (external link)