VX 11e

Name	VX-11e
Synonyms	VX11E VX 11E VX-11e VX 11e VX-11E TCS ERK 11e VX-11e(TCS ERK 11e) TCS ERK 11e (VX-11e) 4-[2-[(2-Chloro-4-fluorophenyl)amino]-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide 1H-Pyrrole-2-carboxaMide, 4-[2-[(2-chloro-4-fluorophenyl)aMino]-5-Methyl-4-pyriMidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-
CAS	896720-20-0

Molecular Formula	C24H20Cl2FN5O2
Molar Mass	500.35
Density	1.447±0.06 g/cm3(Predicted)
pKa	13.65±0.50(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
In vitro study	In HT29 cells, VX-11e effectively inhibited cell proliferation with an IC50 of 48 nM.
In vivo study	In both rats and mice, VX-11e showed good oral bioavailability. In NSG mice bearing human melanoma RPDX tumors, vx-11e (50 mg/kg, p.o.) resulted in strong inhibition of pRSK and inhibition of tumor growth. When used in combination with BKM120, VX-11e resulted in a significant increase in tumor growth inhibition.

Last Update：2024-01-02 23:10:35

biological activity	VX-11e (VTX-11e, Vertex-11e) is an effective, selective, and oral bioavailable ERK2 inhibitor, Ki <2 nM, which is 200 times more selective than kinases acting on other tests.
target	TargetValue ERK2 (Cell-free say) <2 nM(Ki)
Target	Value
ERK2 (Cell-free assay)	<2 nM(Ki)
in vitro study	in HT29 cells, VX-11e effectively inhibit cell proliferation with IC50 of 48 nM.
in vivo studies	in rats and mice, VX-11e showed good oral bioavailability. In NSG mice loaded with human melanoma RPDX tumors, VX-11e (50 mg/kg, p.o.) resulted in strong inhibition of pRSK and inhibition of tumor growth. When combined with BKM120, VX-11e leads to a significant increase in tumor growth inhibition.

Last Update：2024-04-10 22:29:15

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Product Name: VX-11e Visit Supplier Webpage Request for quotation
CAS: 896720-20-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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VX 11e

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